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Updated: 16 min 47 sec ago

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Mon, 10/05/2020 - 09:59
Using ELISpot and proliferation assays, researchers show strong responses in SARS-CoV-2 infected patients, but not so much in negative samples. However, there may be cross-reactive T cell responses from other human coronaviruses.

AbC-19 blood test detects COVID-19 antibodies 20 weeks after first symptoms/PCR positive result

Mon, 10/05/2020 - 09:36
Serological antibody immunoassays are one of the essential tools to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In a new study, Immunoglobulin G (IgG) antibodies are detected in a large cohort, lasting up to 140 days. The researchers propose an alternative to reverse transcription-polymerase chain reaction (RT-PCR) positive status as a standard for assessing SARS-CoV-2 antibody assays and show robust performance metrics for the AbC-19 rapid test.

Investigation of SARS-CoV-2 antibody responses in patients with aggressive hematological malignancies

Mon, 10/05/2020 - 09:13
Patients with hematological malignancy (PHM), also infected with COVID-19, were investigated for SARS-CoV-2 antibody responses while undergoing systemic anti-cancer therapy. While no obvious correlation is found between the serological results and the hematological diagnosis and the treatment, the immune response is similar to the severity of COVID-19 infection observed in the general population.

Higher prevalence of SARS-CoV-2 with D614G mutation in Washington State

Mon, 10/05/2020 - 08:58
The study findings also indicate that the 614G viral variant is associated with higher viral load, but not with disease severity. The study is currently available on the medRxiv preprint server.

The implications of COVID-related sexual distancing and clinical service interruption

Mon, 10/05/2020 - 08:09
A recent study conducted in the Atlanta area reveals that coronavirus disease 2019 (COVID-19) related sexual distancing together with clinical service interruption for sexually transmitted diseases can potentially impact the future incidence of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). The study is currently available on the medRxiv* preprint server.

More evidence Pangolin not intermediary in transmission of SARS-CoV-2 to humans

Mon, 10/05/2020 - 07:52
The team proposed a different model named the ‘circulation model’ to illustrate how SARS-CoV-2-related coronaviruses could have circulated in different species, including humans, before COVID-19 emerged.

NPIs reduced SARS-CoV-2 transmission in South Korea

Mon, 10/05/2020 - 07:22
Although some studies examined how public health interventions can help contain COVID-19 outbreaks, not much information was available on public health measures against SARS-CoV-2 transmission, specifically in South Korea.

A comprehensive clinical and genetic model for predicting severe COVID-19 risk

Mon, 10/05/2020 - 07:10
While determining the risk of severe COVID-19, age, and gender are usually the only considerations. A recent preprint paper published in medRxiv, discusses how researchers from Genetic Technologies Limited, Australia, used the UK Biobank data to develop a comprehensive model that can predict severe COVID-19 risk by incorporating comorbidity risk factors, demographic information, and a set of genetic markers.

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

Mon, 10/05/2020 - 06:36
A large group of researchers from the United States reported developing an amplification-free CRISPR-based mobile phone assay for direct detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from nasal swabs. Their state-of-the-art paper is currently available on the medRxiv* preprint server.

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

Mon, 10/05/2020 - 05:54
In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

Identifying cardiopulmonary processes involved in severe COVID-19

Mon, 10/05/2020 - 05:26
Researchers in the United States have identified cardiopulmonary processes that may partly explain why some individuals with coronavirus disease 2019 (COVID-19) develop respiratory failure.

Modeling viral clades improves prediction of COVID-19 growth rates

Mon, 10/05/2020 - 05:04
A new study conducted by researchers at the University of Connecticut has revealed a correlation between the prevalence of particular clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the growth rate of the associated illness coronavirus disease 2019 (COVID-19).

Shedding light on origin, transmission, spread of COVID-19 in Norfolk

Mon, 10/05/2020 - 04:43
Researchers in the UK have conducted a large-scale whole-genome sequencing study of clinical samples positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Norfolk area to shed light on the origins, genetic variation, transmission, and spread of the virus in the region.

Anti-sense agents suppress SARS-CoV-2 virus

Mon, 10/05/2020 - 04:22
Researchers in the United States have conducted a study showing that anti-sense agents called peptide-conjugated morpholino oligomers (PPMOs) have the ability to specifically and potently suppress the growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.