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Liver trigger holds the key to boosting gene therapy success

Rss Feed - Thu, 12/07/2023 - 19:36
Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in the activation of specific immune cells, despite the liver's typical role in suppressing immune responses.

Large language models enhance differential diagnosis, paving the way for AI-assisted medical decision-making

Rss Feed - Thu, 12/07/2023 - 19:05
Study explores optimizing large language models (LLMs) for differential diagnosis (DDx), demonstrating their potential in assisting clinicians with accurate disease diagnosis using real-world medical cases.

Immunoregulatory nanomedicines for the prevention and treatment of respiratory diseases

Rss Feed - Thu, 12/07/2023 - 18:56
Study explores immunoregulatory nanomedicines for respiratory infections, highlighting their potential in enhancing treatment outcomes and vaccine efficacy.

Study exposes societal stigma and misconceptions about acne

Rss Feed - Thu, 12/07/2023 - 18:41
Study reveals societal stigma and negative stereotypes associated with acne, highlighting the need for greater awareness and understanding of this skin condition.

Maternal inflammation risk factors linked to dysregulation in children

Rss Feed - Thu, 12/07/2023 - 15:20
Maternal inflammation risk factors may be associated with dysregulation in children, according to a study funded by the Environmental influences on Child Health Outcomes (ECHO) Program at the National Institutes of Health.

Novel mechanism leads to motor neuron degeneration in spinal muscular atrophy

Rss Feed - Thu, 12/07/2023 - 15:13
The lab of Yongchao C. Ma, PhD, at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago uncovered a novel mechanism that leads to motor neuron degeneration in spinal muscular atrophy (SMA).

Breakthrough discovery paves the way for new methods to detect and treat leukemia

Rss Feed - Thu, 12/07/2023 - 14:56
Researchers led by François Fuks - Laboratory of Cancer Epigenetics, ULB Faculty of Medicine, ULB Cancer Research Center and Jules Bordet Institute, H.U.B. - have made a major breakthrough in the understanding and treatment of leukemia.

Early treatment offers chance at medication-free remission for pediatric HIV patients

Rss Feed - Thu, 12/07/2023 - 14:49
An unexpectedly high percentage of children, who were born with HIV and started treatment within 48 hours of life, exhibit biomarkers by 2 years of age that may make them eligible to test for medication-free remission, according to a multinational study published in Lancet HIV.

Study finds link between epimutations in BRCA1 gene and triple-negative breast cancer risk

Rss Feed - Thu, 12/07/2023 - 14:34
Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene.

IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

Rss Feed - Thu, 12/07/2023 - 14:22
Almost all postmenopausal patients aged 50-69 years with stage I hormone receptor (HR)-positive breast cancer and low scores on a common genetic test who opted out of adjuvant radiotherapy were disease free five years after surgery, according to results from the IDEA clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

Exercise may become part of standard treatment for metastatic breast cancer, study suggests

Rss Feed - Thu, 12/07/2023 - 14:10
Among patients with metastatic breast cancer, those who took part in a nine-month structured exercise program reported less fatigue and an improved quality of life compared to those who did not undergo the exercise program, according to results from the PREFERABLE-EFFECT trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

Working night shifts associated with higher occurrence of disordered sleep

Rss Feed - Thu, 12/07/2023 - 13:42
Sleep is critical for daytime and neurocognitive functioning, as well as physical and mental health. When people work shifts – in 2015, 21% of workers in the European Union did – their circadian sleep-wake rhythms are commonly disrupted.

Can oral contraceptive therapy improve the vaginal microbiome in women with PCOS?

Rss Feed - Thu, 12/07/2023 - 08:56
The impact of the contraceptive medication-induced change in hormonal levels on the vaginal microbiome.

Associations between low-inflammatory diets and diabetes risk

Rss Feed - Thu, 12/07/2023 - 08:26
Associations between a low-inflammatory diet and type 2 diabetes (T2D) risk.

Promising candidate medication for preventing and reversing fentanyl-induced overdose

Rss Feed - Thu, 12/07/2023 - 08:19
Researchers assessed CSX-1004, a monoclonal antibody (mAb), for its efficacy in reversing fentanyl overdose based on its high affinity for fentanyl, positive animal model results, and safe pharmacokinetic profile, positioning it as a potential solution in the opioid crisis.

What's my age again? Predicting disease and aging effects by studying organ aging using plasma proteomics data

Rss Feed - Thu, 12/07/2023 - 07:56
Researchers performed a proteomic analysis to identify serologic indicators of organ aging and disease.

The association between viral infections and glioma risk

Rss Feed - Thu, 12/07/2023 - 07:55
The causal relationship between viral infection and glioma.

Psychotria malayana Jack leaf extract could effectively treat diabetes with lower toxicity

Rss Feed - Thu, 12/07/2023 - 06:41
Psychotria malayana Jack leaf extract (OE) to evaluate its anti-diabetic, anti-inflammatory, and antioxidant properties.

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