Life Quality and Cytokines Profile in Patients with Asthma and Osteoarthritis

Yuliya S. Ivanchuk, Ludmila V. Tribuntceva, Andrey V. Budnevsky, Yanina S. Shkatova, Evgeniy S. Ovsyannikov, Roman E. Tokmachev

 
International Journal of Biomedicine. 2021;11(2):137-140.
DOI: 10.21103/Article11(2)_OA2
Originally published June 5, 2021

Abstract: 

The objective of this study was to evaluate levels of leptin, adiponectin, IL-4, IL-6, TNF-α, oxidative damage, and antioxidant status in patients with bronchial asthma (BA), compared to patients who suffer from both BA and osteoarthritis (OA), and analyze the quality of life in such patients.
Methods and Results: The study included 103 patients (34 men and 69 women) diagnosed with moderate asthma aged from 30 to 70 years (mean age of 58.52±7.14 years). The levels of IL-4, IL-6, TNF-α, adiponectin, leptin, total antioxidant status (TAS), and total oxidative damage (TOD) were measured. Two questionnaires were used in this study: Asthma Quality of Life Questionnaire (AQLQ) and Asthma Control Test (АСТ).
The levels of leptin, TNF-α, and Il-6 were significantly higher in Group 2 than in Group 1. On the contrary, the IL-4 level was higher in Group 1 than in Group 2. The TAS value was significantly higher in Group 1 than in Group 2 (P=0.0001). The TOD value ​​was significantly higher in Group 2 than in Group 1 (P=0.0000). The domains of AQLQ(S) activity, symptoms, and emotions were decreased in patients of Group 2. The values of the ACT test were 18.0±2.61 points and 16.78±1.92 points in Group 1 and Group 2, respectively (P=0.0077).
Conclusion: In patients with both asthma and osteoarthritis, levels of inflammatory cytokines, such as leptin, IL-6, and TNF-α, are significantly elevated as well as values of total oxidative status, which correlate with poorer asthma control and quality of life.

Keywords: 
asthma • osteoarthritis • IL-6 • TNF-α • quality of life
References: 

1. Rehman A, Amin F, Sadeeqa S. Prevalence of asthma and its management: A review. J Pak Med Assoc. 2018 Dec;68(12):1823-1827.
2. McGeachie MJ, Wang AL, Lutz SM, Sordillo JE, Weiss ST, Tantisira KG, Iribarren C, Lu MX, Wu AC. Real-Life Patterns of Exacerbations While on Inhaled Corticosteroids and Long-Acting Beta Agonists for Asthma over 15 Years. J Clin Med. 2020 Mar 18;9(3):819. doi: 10.3390/jcm9030819.
3. Tsvetikova LN, Budnevsky AV, Ovsyannikov ES, Kudashova EA. Melatonin: Possibilities for use in the treatment of asthma. Ter Arkh. 2017;89(3):112–5. Russian. doi: 10.17116/terarkh2017893112-115.
4. Brussino L, Solidoro P, Rolla G. Is it severe asthma or asthma with severe comorbidities? J Asthma Allergy. 2017 Nov 29;10:303-305. doi: 10.2147/JAA.S150462.
5. Budnevsky A, Tribuntceva L, Kozhevnikova S, Ovsyannikov E. Impact of Metabolic Syndrome Components on Asthma Control and Life Quality of Patients. International Journal of Biomedicine. 2018;8(1):33–6. doi: 10.21103/article8(1)_oa4.
6. Budnevsky AV, Isaeva YV, Malysh EY, Kozhevnikova SA. Legochnaya reabilitatsiya kak effektivnyi metod optimizatsii lechebno-profilakticheskikh meropriyatii u bol'nykh khronicheskoi obstruktivnoi bolezn'yu legkikh s metabolicheskim sindromom [Pulmonary rehabilitation as an effective method for optimizing therapeutic and preventive measures in patients with chronic obstructive pulmonary disease concurrent with metabolic syndrome]. Ter Arkh. 2016;88(8):25-29. Russian. doi: 10.17116/terarkh201688825-29.
7. Budnevsky AV, Malysh EY, Ovsyannikov ES, Drobysheva ES. Bronkhial'naia astma i metabolicheskiĭ sindrom: kliniko-patogeneticheskie vzaimosviazi [Asthma and metabolic syndrome: Clinical and pathogenetic relationships]. Ter Arkh. 2015;87(10):110-114. doi: 10.17116/terarkh20158710110-114. [Article in Russian].
8. Ermolova AV, Budnevsky AV, Yu ME, Ovsyannikov ES, Drobysheva ES. [BRONCHIAL ASTHMA AND METABOLIC SYNDROME]. Klin Med (Mosk). 2015;93(6):44-9. [Article in Russian].
9. Steppuhn H, Langen U, Keil T, Scheidt-Nave C. Chronic disease co-morbidity of asthma and unscheduled asthma care among adults: results of the national telephone health interview survey German Health Update (GEDA) 2009 and 2010. Prim Care Respir J. 2014 Mar;23(1):22-9. doi: 10.4104/pcrj.2013.00107.
10. Koo HK, Song P, Lee JH. Novel association between asthma and osteoarthritis: a nationwide health and nutrition examination survey. BMC Pulm Med. 2021 Feb 16;21(1):59. doi: 10.1186/s12890-021-01425-6.
11. Mahmood ZA, Malghooth ZT. Relationship of Hips and Knees Osteoarthritis with Bronchial Asthma. Res J Pharm Biol Chem Sci. 2019; 10(2): 64-70.
12. Ghebre MA, Pang PH, Desai D, Hargadon B, Newby C, Woods J, Rapley L, Cohen SE, Herath A, Gaillard EA, May RD, Brightling CE. Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum. BMC Pulm Med. 2019 Aug 8;19(1):144. doi: 10.1186/s12890-019-0906-7.
13. Dimitrova D, Youroukova V, Ivanova-Todorova E, Tumangelova-Yuzeir K, Velikova T. Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma. Respir Med. 2019 Jul-Aug;154:144-154. doi: 10.1016/j.rmed.2019.06.024.
14. Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, Spector TD. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum. 2009 Jul;60(7):2037-45. doi: 10.1002/art.24598.
15. Imamura M, Ezquerro F, Marcon Alfieri F, Vilas Boas L, Tozetto-Mendoza TR, Chen J, Özçakar L, Arendt-Nielsen L, Rizzo Battistella L. Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization. Int J Inflam. 2015;2015:329792. doi: 10.1155/2015/329792.
16. Matsusaka M, Fukunaga K, Kabata H, Izuhara K, Asano K, Betsuyaku T. Subphenotypes of type 2 severe asthma in adults. J Allergy Clin Immunol Pract. 2018 Jan-Feb;6(1):274-276.e2. doi: 10.1016/j.jaip.2017.06.015.
17. Provotorov VM, Budnevskiĭ AV, Semenkova GG, Shishkina ES. [PROINFLAMMATORY CYTOKINES IN COMBINATION OF CORONARY HEART DISEASE AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE]. Klin Med (Mosk). 2015;93(2):5-9. [Article in Russian].
18. Morales Abaunza RA, Rojas ÁP, Rojas C, Motta O, Atuesta J, Alzate JP, et al. Levels of serum leptin in patients with primary hand osteoarthritis. Rev Colomb Reumatol. 2020;27:20–25. doi: 10.1016/j.rcreue.2019.12.005.
19. Yan M, Zhang J, Yang H, Sun Y. The role of leptin in osteoarthritis. Medicine (Baltimore). 2018 Apr;97(14):e0257. doi: 10.1097/MD.0000000000010257.
20. Budnevsky AV, Ovsyannikov ES, Labzhania NB. Sochetanie khronicheskoĭ obstruktivnoĭ bolezni legkikh i metabolicheskogo sindroma: patofiziologicheskie i klinicheskie osobennosti [Chronic obstructive pulmonary disease concurrent with metabolic syndrome: Pathophysiological and clinical features]. Ter Arkh. 2017;89(1):123-127. doi: 10.17116/terarkh2017891123-127. [Article in Russian].
21. Zheng H, Wu D, Wu X, Zhang X, Zhou Q, Luo Y, Yang X, Chock CJ, Liu M, Yang XO. Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway. Sci Rep. 2018 Jun 11;8(1):8905. doi: 10.1038/s41598-018-27278-4.
22. Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002;39(1-2):237-46.
23. Ren J, Sun Y, Li G, Zhu XJ, Cui JG. Tumor necrosis factor-α, interleukin-8 and eosinophil cationic protein as serum markers of glucocorticoid efficacy in the treatment of bronchial asthma. Respir Physiol Neurobiol. 2018 Dec;258:86-90. doi: 10.1016/j.resp.2018.06.004.
24. Zahan OM, Serban O, Gherman C, Fodor D. The evaluation of oxidative stress in osteoarthritis. Med Pharm Rep. 2020 Jan;93(1):12-22. doi: 10.15386/mpr-1422.
25. Provotorov VM, Budnevsky AV, Filatova YI, Perfil'eva MV. [ANTIOXIDANT THERAPY OF BRONCHIAL ASTHMA]. Klin Med (Mosk). 2015;93(8):19-22. [Article in Russian).

Download Article
©2021 International Medical Research and Development Corporation.