Mechanism of Cell Cycle Asynchrony within the Animal Organism

Michael T. Lucenko, PhD, ScD, Academician of RAMS

Far Eastern Scientific Center of Physiology and Pathology of Respiration, Siberian Branch of Russian Academy of Medical Sciences, Blagoveshchensk, Russian Federation

*Corresponding author: Prof. Michael T. Lucenko, Academician of RAMS, Far Eastern Scientific Center of Physiology and Pathology of Respiration SB of RAMS, 95A, Gorky str., 675000, Blagoveshchensk, Russian Federation E-mail:

Published: March 25, 2013


Every organism is composed of multi-cellular systems. Each of these cells, from the time of birth until death, often plays a polyfunctional role. Obviously, this cycle must include periods of intense work and leisure. In other words, the organ cell masses are able to perform the asynchronous mechanism of cell cycle. The implementation of such a mechanism is regulated by the cell’s gene apparatus which receives the signal from the cytosol of the functioning cell; it also performs the reverse inclusion of the cells doing the work after the rest interval. The aim of this study was to show the presence of a daily regulation of the cell apparatus of any organ, using the liver as an example. This phenomenon is the obligatory mechanism developed over the course of a long evolution and explains the lifetime of the multicellular organ system.

hepatocyte; cell cycle; nucleus; asynchronous operation.

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Int J Biomed. 2013; 3(1):41-43. © 2013 International Medical Research and Development Corporation. All rights reserved.