Encephalon Condition in Chronic Alcohol Intoxication and the Role of Amoebic Invasion of this Organ in the Development of Ethanol Attraction in Men

BASIC RESEARCH
Sergey V. Shormanov, PhD, ScD

The Yaroslavl Medical Academy;Yaroslavl, Russian Federation

*Corresponding author:  Prof. Sergey V. Shormanov. The Yaroslavl Medical Academy, Yaroslavl, Russian Federation. E-mail: S_V_Shormanov@rambler.ru

Published: December 25, 2013 

Abstract: 

This presentation reviews data from studies on the encephalon in 27 men ranging in age from 21 to 51 years, showing signs of chronic alcohol intoxication and who died from causes other than skull injury and 14 control subjects. The specimens were fixed in formalin or Karnua liquid, filled with paraffin and then examined, utilizing a variety of histological, histochemical and morphometric techniques. The data refers to the structural changes in the various tissue components of the brain (nervous, glia-cells, arteries, veins), as well as pertinent information concerning the presence of Protozoa in all the sections examined which according to their morphological signs and behavioral reactions indicate that amoeba had been present. The degree of cerebral tissue insemination by these parasites has been demonstrated. The condition of the membranes of these microorganisms, their cytoplasm, nucleus and nucleoli as well as the chromatoid corpuscles has been assessed and recorded. The ability of these microorganisms to split, migrate within the CNS limits, to trigger incitement and dystrophic changes and in the case of death – calcification or exulceration is shown. Further, the issue of species characteristics of amoeba occurring in the patients’ brains is discussed. The hypothesis of a possible link of amebic invasion with the development of alcohol dependence in humans is proposed.

Keywords: 
encephalon brain; chronic alcohol intoxication; amoebae role in the pathogenesis of alcoholism.
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Int J Biomed. 2013; 3(4):279-282. © 2013 International Medical Research and Development Corporation. All rights reserved.