NO Metabolism in Red Blood Cells and the Hemoglobin Oxygenation in Pregnant Women with the Cytomegalovirus Infection Exacerbation

CLINICAL RESEARCH
Michael T. Lucenko, PhD, ScD*; Irina A. Andrievskaya, PhD, ScD; Inna V. Dovzhikova

Far Eastern Scientific Center of Physiology and Pathology of Respiration, Siberian Branch of Russian Academy of Medical Sciences; Blagoveshchensk, Russian Federation

*Corresponding author: Prof. Michael T. Lucenko, PhD, ScD, Academician of RAMS, Head of Far Eastern Scientific Center of Physiology and Pathology of Respiration SB of RAMS. Blagoveshchensk, Russian Federation. E-mail: Lucencomt@mail.ru

Published: September 20, 2014. 

Abstract: 

CMV infection during pregnancy induces a number of N-nitrosation reactions in erythrocytes, which violate process of normal hemoglobin oxygenation. Abnormalities in the L-arginine-NO system cause a decrease in the antioxidant capacity of red blood cells, which is associated with reducing the amount of glutathione reductase, glutathione peroxidase and superoxide dismutase. 

Keywords: 
cytomegalovirus; pregnancy; L-arginine-NO system; hemoglobin oxygenation.
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Int J Biomed. 2014; 4(3):151-154. © 2014 International Medical Research and Development Corporation. All rights reserved.