Advances in the Management of Sleep Disorders in Juvenile Myoclonic Epilepsy

Polina V. Moskaleva, Olga S. Shilkina, Natalia A. Shnayder, Ivan P. Artyukhov, Diana V. Dmitrenko, Elena A. Yuryeva

 
International Journal of Biomedicine. 2018;8(2):108-114.   
DOI: 10.21103/Article8(2)_RA3
Originally published June 15, 2018  

Abstract: 

Juvenile myoclonic epilepsy (JME) is a well-defined sub-syndrome of idiopathic generalized/genetic epilepsy, usually presenting in adolescence and characterized by myoclonic jerks, predominately in the arms, associated with tonic-clonic seizures and less often generalized absences. Although the evidence base for a relationship between JME and sleep disorders is weak, most experts regard sleep disorders as an actual comorbidity. This paper reviews the literature underpinning the development of sleep disorders in JME patients. Data that report associated causes of sleep problems in JME patients are discussed, as is the importance of counseling on lifestyle issues. Lastly, a practical approach to managing sleep disorders in young men and women with JME is summarized.

Keywords: 
juvenile myoclonic epilepsy • sleep • comorbidity • managment
References: 
  1. Brain Basics: Understanding Sleep. Office of Communications and Public Liaison, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda. 2017 Available from: https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Understa...
  2. Sleep-wake cycle: its physiology and impact on health. National Sleep Foundation. 2006. Available from: www.sleepfoundation.org
  3. Schmitt B. Sleep and epilepsy syndromes. Neuropediatrics. 2015; 46(3): 171-80. doi: 10.1055/s-0035-1551574. PubMed
  4. Grigg-Damberger MM, Ralls F. Sleep disorders in adults with epilepsy: past, present, and future directions. Curr Opin Pulm Med. 2014;20(6):542-9. doi: 10.1097/MCP.0000000000000101. PubMed
  5. Malow BA, Vaughn BV. Treatment of sleep disorders in epilepsy. Epilepsy Behav. 2002;3(5S):35-37. PubMed
  6. O'Muircheartaigh J, Vollmar C, Barker GJ, Kumari V, Symms MR, Thompson P, et al. Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy. Brain. 2012;135 (Pt 12):3635-44. doi: 10.1093/brain/aws296. PubMed
  7. Dennis GJ. The relationship between sleep and epilepsy. ACNR. 2016;16(2):13-16. 
  8. Wandschneider B, Thompson PJ, Vollmar C, Koepp MJ. Frontal lobe function and structure in juvenile myoclonic epilepsy: a comprehensive review of neuropsychological and imaging data. Epilepsia. 2012;53(12):2091-8. doi: 10.1111/epi.12003. PubMed
  9. Shahnaz, Sher K, Abdul Sattar R. Clinical and EEG characteristics of juvenile myoclonic epilepsy. Pak J Med Sci. 2014;30(1):12-5. doi: 10.12669/pjms.301.4465. PubMed
  10. Lee JM, Kim SY, Hwang YH, Lee HW, Suh CK, Park SP. [Longitudinal assessment of cognitive function in patients with juvenile myoclonic epilepsy]. J Korean Epilepsy Soc. 2008;12(2):85-91. [Article in Korean]. Google Scholar
  11. Motamedi M, Nasergivehch S, Karamghadiri N, Noroozian M. Juvenile myoclonic epilepsy (JME): neuropsychological profile and related factors with cognitive dysfunction. Iran J Psychiatry. 2014;9(1):14-19. PubMed
  12. Gunatilake SB, Seneviratne SL. Juvenile myoclonic epilepsy: a study in Sri Lanka. Seizure. 2000;9(3):221-3. PubMed
  13. Panayiotopoulos CP, Obeid T, Tahan AR. Juvenile myoclonic epilepsy: a 5-year prospective study. Epilepsia. 1994;35(2):285-96. PubMed
  14. Aliberti V, Grünewald RA, Panayiotopoulos CP, Chroni E. Focal electroencephalographic abnormalities in juvenile myoclonic epilepsy. Epilepsia. 1994;35(2):297-301. PubMed
  15. Jain SV, Kothare SV. Sleep and Epilepsy. Semin Pediatr Neurol. 2015;22(2):86-92. doi: 10.1016/j.spen.2015.03.005. PubMed
  16. Roshan S, Puri V, Chaudhry N, Gupta A, Rabi SK. Sleep abnormalities in juvenile myoclonic epilepsy-A sleep questionnaire and polysomnography based study. Seizure. 2017;50:194-201. doi: 10.1016/j.seizure.2017.06.021. PubMed
  17. Gigli GL, Calia E, Marciani MG, Mazza S, Mennuni G, Diomedi M, et al. Sleep microstructure and EEG epileptiform activity in patients with juvenile myoclonic epilepsy. Epilepsia. 1992;33(5):799-804. PubMed
  18. Ramachandraiah CT, Sinha S, Taly AB, Rao S, Satishchandra P. Interrelationship of sleep and juvenile myoclonic epilepsy (JME): a sleep questionnaire-, EEG-, and polysomnography (PSG)-based prospective case-control study. Epilepsy Behav. 2012;25(3):391-6. doi: 10.1016/j.yebeh.2012.08.009. PubMed
  19. Krishnan P, Sinha S, Taly AB, Ramachandraiah CT, Rao S, Satishchandra P. Altered polysomnographic profile in juvenile myoclonic epilepsy. Epilepsy Res. 2014;108(3):459-67. doi: 10.1016/j.eplepsyres.2013.12.007. PubMed
  20. Giorgi FS, Guida M, Caciagli L, Pagni C, Pizzanelli C, Bonanni E, et al. Social cognition in juvenile myoclonic epilepsy. Epilepsy Res. 2016;128:61-67. doi: 10.1016/j.eplepsyres.2016.10.017. PubMed
  21. Lin JJ, Dabbs K, Riley JD, Jones JE, Jackson DC, Hsu DA, et al. Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years. Ann Neurol. 2014;76(5):660-8. doi: 10.1002/ana.24240. PubMed
  22. Kim JH, Lee JK, Koh SB, Lee SA, Lee JM, Kim SI, Kang JK. Regional grey matter abnormalities in juvenile myoclonic epilepsy: a voxel-based morphometry study. Neuroimage. 2007;37(4):1132-7. PubMed
  23. Fukuda A, Funari MP, Fernandes PT, Guerreiro CM, Li LM. Circadian rhythm and profile in patients with juvenile myoclonic epilepsy and temporal lobe epilepsy. Arq Neuropsiquiatr. 2015; 73(1):3-6. doi: 10.1590/0004-282X20140190. PubMed
  24. Leahy T, Hennessy MJ, Counihan TJ. The "Cinderella Syndrome": A narrative study of social curfews and lifestyle restrictions in juvenile myoclonic epilepsy. Epilepsy Behav. 2017;78:104-108. doi: 10.1016/j.yebeh.2017.10.024. PubMed
  25. England MJ, Liverman CT, Schultz AM, Strawbridge LM. Epilepsy across the spectrum: promoting health and understanding. A summary of the Institute of Medicine report. Epilepsy Behav. 2012;25(2):266-76. doi: 10.1016/j.yebeh.2012.06.016. PubMed
  26. Shen Y, Zhang M, Wang Y, Wang L, Xu X, Xiao G, et al. Subjective sleep disturbance in Chinese adults with epilepsy: Associations with affective symptoms. Epilepsy Res. 2017;135:150-157. doi: 10.1016/j.eplepsyres.2017.06.014. PubMed
  27. Janz D, Christian W. Impulsive petit-mal. Deutsche Zeitschrift für  Nervenheilkunde 176:346–386. (English translation by Genton P. 1994). In: Malafosse A, Genton P, Hirsch E, Marescaux C, Broglin D, Bernasconi M. (eds.) 1994;1957:229–251.
  28. de Araujo Filho GM, Yacubian EM. Juvenile myoclonic epilepsy: psychiatric comorbidity and impact on outcome. Epilepsy Behav. 2013;28 Suppl 1:S74-80. doi: 10.1016/j.yebeh.2013.03.026. PubMed
  29. Camfield CS, Camfield PR. Juvenile myoclonic epilepsy 25 years after seizure onset: a population-based study. Neurology. 2009;73(13):1041-5. doi: 10.1212/WNL.0b013e3181b9c86f. PubMed
  30. Caplan R, Siddarth P, Gurbani S, Hanson R, Sankar R, Shields WD. Depression and anxiety disorders in pediatric epilepsy. Epilepsia. 2005;46(5):720-30. PubMed
  31. Somayajula S, Vooturi S, Jayalakshmi S. Psychiatric disorders among 165 patients with juvenile myoclonic epilepsy in India and association with clinical and sociodemographic variables. Epilepsy Behav. 2015;53:37-42. doi:10.1016/j.yebeh.2015.09.024. PubMed
  32. Moskaleva PV, Shilkina OS, Artyukhov IP, Strotskaya IG, Dmitrenko DV, Shnayder NA. Nonpsychotic psychiatric disorders in juvenile myoclonic epilepsy. International Journal of Biomedicine. 2017;7(2):85-90. doi: 10.21103/Article7(2)_RA1. Google Scholar
  33. Delgado-Escueta AV, Koeleman BP, Bailey JN, Medina MT, Durón RM. The quest for juvenile myoclonic epilepsy genes. Epilepsy Behav. 2013;28 Suppl 1:S52-7. doi: 10.1016/j.yebeh.2012.06.033. PubMed
  34. Sammaritano M, Sherwin A. Effect of anticonvulsants on sleep. Neurology. 2000;54(5 Suppl 1):S16-24. PubMed
  35. Vaughn BV, D'Cruz OF, Beach R, Messenheimer JA. Improvement of epileptic seizure control with treatment of obstructive sleep apnea. Seizure. 1996;5(1):73-8. PubMed
  36. Foldvary-Schaefer N. Sleep complaints and epilepsy: the role of seizures, antiepileptic drugs and sleep disorders. J Clin Neurophysiol. 2002;19(6):514-21. PubMed
  37. Roder-Wanner UU, Noachter S, Wolf P. Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate short and long-term effects. Acts Neurol Scand. 1987;76(3):157-67. PubMed
  38. Wolf P, Roder-Wanner UU, Brede M. Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy. Epilepsia.1984; 25(4):467-75. PubMed
  39. Sabatowski R, Gálvez R, Cherry DA, Jacquot F, Vincent E, Maisonobe P, Versavel M; 1008-045 Study Group. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomized, placebo-controlled trial. Pain. 2004;109(1-2):26-35. PubMed
  40. Gigli GL, Placidi F, Diomedi M, Maschio M, Silvestri G, Scalise A, Marciani MG. Nocturnal sleep and daytime somnolence in untreated patients with temporal lobe epilepsy: changes after treatment with controlled release carbamazepine. Epilepsia. 1997;38(6):696-701. PubMed
  41. Copinschi G, Van Onderbergen A, L'Hermite-Balériaux M, Szyper M, Caufriez A, Bosson D, et al. Effects of short-acting benzodiazepine triazolam, taken at bedtime on circadian and sleep-related hormonal profiles in normal men. Sleep. 1990;13(3):232-44. PubMed
  42. Sammaritano M, Sherwin AL. Effects of anticonvulsants on sleep. In: Bazil CW, Malow BA, Sammaritano MR, editors. Sleep and epilepsy: the clinical spectrum. Amsterdam: Elsevier; 2002:187-194. 
  43. Brodie MJ. Modern management of juvenile myoclonic epilepsy. Expert Rev Neurother. 2016; 16(6):681-8. doi: 10.1080/14737175.2016.1179113. PubMed
  44. Nayak CS, Sinha S, Nagappa M, Kandavel T, Taly AB. Effect of valproate on the sleep microstructure of juvenile myoclonic epilepsy patients – a cross-sectional CAP based study. Sleep Med. 2016;17:129-33. doi: 10.1016/j.sleep.2015.11.006. PubMed
  45. Guilleminault C. Benzodiazepines, breathing, and sleep. Am J Med. 1990; 2;88(3A):25S-28S. PubMed
  46. Baykan B, Martínez-Juárez IE, Altindag EA, Camfield CS, Camfield PR. Lifetime prognosis of juvenile myoclonic epilepsy. Epilepsy Behav. 2013;28 Suppl 1:S18-24. doi: 10.1016/j.yebeh.2012.06.036. PubMed
  47. Artyukhov IP, Shilkina OS, Shnayder NA, Dmitrenko DV, Bochanova EN, Shapovalova EA, Strotskaya IG. Case report of management problem of juvenile myoclonic epilepsy. Case Rep Clin Med. 2016;5:217–224. doi: 10.4236/crcm.2016.57040. Google Scholar
  48. Artyukhov IP, Shilkina OS, Shnayder NA, Dmitrenko DV, Bochanova EN, Babina IS. Paradigms of management of juvenile myoclonic epilepsy. Archiv Euromedica. 2016;6(2):2-7. Google Scholar
  49. Shilkina O, Petrov K, Diuzhakova A, Marueva N, Shnayder N. Frequency of juvenile myoclonic epilepsy clinical phenotypes in Siberia. World J Neurosci. 2016; 6:32-36. doi: 10.4236/wjns.2016.61004. Google Scholar
  50. Shnayder NA, Shilkina OS, Petrov KV, Chernykh IA, Diuzhakova AV. [Clinical and genetic heterogenity of juvenile myoclonic epilepsy]. Epilepsia and Paroxyzmal Conditions. 2016; 8(2):20-36. doi:10.17749/2077-8333.2016.8.2.020-036. [Article in Russian]. Google Scholar
  51. Rocamora R, Sánchez-Alvarez JC, Salas-Puig J. The relationship between sleep and epilepsy. Neurologist. 2008;14(6 Suppl 1):S35-43. doi: 10.1097/01.nrl.0000340790.15295.59. PubMed
  52. Kotov AS. [Anxiety in epileptic patients]. Zh Nevrol Psikhiatr Im SS Korsakova. 2013;113(4 Pt 2):41-4. [Article in Russian]. PubMed
  53. Moschetta S, Valente KD. Impulsivity and seizure frequency, but not cognitive deficits, impact social adjustment in patients with juvenile myoclonic epilepsy. Epilepsia. 2013;54(5):866-70. doi: 10.1111/epi.12116. PubMed
  54. Chan S, Baldeweg T, Cross JH. A role for sleep disruption in cognitive impairment in children with epilepsy. Epilepsy Behav. 2011;20(3):435-40. doi: 10.1016/j.yebeh.2010.12.047. PubMed
  55. Parisi P, Bruni O, Pia Villa M, Verrotti A, Miano S, Luchetti A, Curatolo P. The relationship between sleep and epilepsy: the effect on cognitive functioning in children. Dev Med Child Neurol. 2010;52(9):805-10. doi: 10.1111/j.1469-8749.2010.03662.x. PubMed

Download Article
Received March 9, 2018.
Accepted March 19, 2018.
©2018 International Medical Research and Development Corporation.