Compensation of a Cavitary Bone Defect in Conditions of Implantation of Mesh Structures from Titanium Nickelide

Yuri M. Iryanov, Nikolay A. Kiryanov

International Journal of Biomedicine. 2018;8(4):337-341.   
DOI: 10.21103/Article8(4)_OA14
Originally published December 15, 2018  


The purpose of our research was to study reparative osteogenesis for implanting mesh structures of titanium nickelide (TN) into a cavitary bone defect.
Methods: The authors modeled cavitary defects of femoral metaphysis experimentally in Wistar rats divided into an experimental and a control group. The study duration was 60 days in total. Scanning electron microscope JSM-840 (JEOL, Japan) equipped with energy dispersive X-ray analyzer (INCA 200, Oxford Instruments) was used.
Results: Under implantation, the defect was filled with cancellous bone the volumetric density of which exceeded control values more than 1.5-fold (P< 0.001). The implant had biocompatibility, osteoconductive and osteoinductive properties, and it stopped inflammatory processes. The membrane protective barrier, which prevented connective tissue sprouting, was formed on the surface of the implant in the defect periosteal zone. The osteointegrative junction was formed and persisted up to the end of the experiment. Reparative osteogenesis was performed by direct intramembranous and apposition type.
Conclusion: The implant of three-dimensional mesh titanium-nickelide structures has marked osteoplastic properties, and it can be successfully used in orthopedic surgery.

reparative osteogenesis • titanium nickelide implant • cavitary bone defect • osteoplastic properties

1. Liu J, Kerns DG. Mechanisms of guided bone regeneration: a review. Open Dent J. 2014;8:56-65. doi: 10.2174/1874210601408010056. PubMed
2. Jung RE, Fenner N, Hämmerle CH, Zitzmann NU. Long-term outcome of implants placed with guided bone regeneration (GBR) using resorbable and non-resorbable membranes after 12-14 years. Clin Oral Implants Res. 2013;24(10): 1065-73. doi: 10.1111/j.1600-0501.2012.02522.x. PubMed
3. Hämmerle CH, Jung RE. Bone augmentation by means of barrier membranes. Periodontol. 2003;33:36-53. PubMed
4. Karring T, Nyman S, Gottlow J, Laurell L. Development of the biological concept of guided tissue regeneration--animal and human studies. Periodontol. 2000;1:26-35. PubMed
5. Schmidmaier G, Baehr K, Mohr S, Kretschmar M, Beck S, Wildemann B. Biodegradable polylactide membranes for bone defect coverage:  biocompatibility testing, radiological and histological evaluation in a sheep model. Clin Oral Implants Res. 2006;17(4):439-44. PubMed
6. van Leeuwen AC, Huddleston Slater JJ, Gielkens PF, de Jong JR, Grijpma DW, Bos RR. Guided bone regeneration in rat mandibular defects using resorbable poly(trimethylene carbonate) barrier membranes. Acta Biomater. 2012;8(4):1422-9. doi: 10.1016/j.actbio.2011.12.004. PubMed
7. Dahlin C, Linde A, Gottlow J, Nyman S. Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg. 1988;81(5):672-6. PubMed
8. Urist MR, McLean FC. Recent advances in physiology of bone. I. J Bone Joint Surg Am. 2003;45:1305-13.
 9. Dahlin C, Sennerby L, Lekholm U, Linde A, Nyman S. Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits. Int J Oral Maxillofac Implants. 1989;4(1):19-25. PubMed
10. Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003;23(4):313-23. PubMed
 11. Iasella JM, Greenwell H, Miller RL, Hill M, Drisko C, Bohra AA, Scheetz JP. Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol. 2003;74(7):990-9. PubMed
12. Iriyanov YM, Chernov VF, Radchenko SA, Chernov AV. Plastic efficiency of different implants used for repair of soft and bone tissue defects. Bull Exp Biol Med.  2013;155(4):518-21. PubMed
13. Iryanov YuM, Iryanova TYu. The implant to replace bone defect. RF Patent 111759. Bul 36;2011:1 [in Russian].
14. Uebersax L, Hagenmüller H, Hofmann S, Gruenblatt E, Müller R, Vunjak-Novakovic G, et al. Effect of scaffold design on bone morphology in vitro. Tissue Eng. 2006;12(12):3417-29. PubMed
15. Osyczka AM, Diefenderfer DL, Bhargave G, Leboy PS. Different effects of BMP-2 on marrow stromal cells from human and rat bone. Cells Tissues Organs. 2004;176(1-3):109-19. PubMed

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Received August 30, 2018.
Accepted September 24, 2018.
©2018 International Medical Research and Development Corporation.