International Journal of Biomedicine. 2018;8(4):337-341.
Originally published December 15, 2018
The purpose of our research was to study reparative osteogenesis for implanting mesh structures of titanium nickelide (TN) into a cavitary bone defect.
Methods: The authors modeled cavitary defects of femoral metaphysis experimentally in Wistar rats divided into an experimental and a control group. The study duration was 60 days in total. Scanning electron microscope JSM-840 (JEOL, Japan) equipped with energy dispersive X-ray analyzer (INCA 200, Oxford Instruments) was used.
Results: Under implantation, the defect was filled with cancellous bone the volumetric density of which exceeded control values more than 1.5-fold (P< 0.001). The implant had biocompatibility, osteoconductive and osteoinductive properties, and it stopped inflammatory processes. The membrane protective barrier, which prevented connective tissue sprouting, was formed on the surface of the implant in the defect periosteal zone. The osteointegrative junction was formed and persisted up to the end of the experiment. Reparative osteogenesis was performed by direct intramembranous and apposition type.
Conclusion: The implant of three-dimensional mesh titanium-nickelide structures has marked osteoplastic properties, and it can be successfully used in orthopedic surgery.
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Received August 30, 2018.
Accepted September 24, 2018.
©2018 International Medical Research and Development Corporation.