Circulating Immune Complexes in Pregnancy Complicated by Chronic Cytomegalovirus Infection

CLINICAL RESEARCH
Michael T. Lucenko, PhD, ScD*; Irina A. Andrievskaya, PhD, ScD

Far Eastern Scientific Center of Physiology and Pathology of Respiration,Siberian Branch of Russian Academy of Medical Sciences,Blagoveshchensk, Russian Federation

*Corresponding author: Prof. Michael T. Lucenko, PhD, ScD, Academician of RAMS, Head of Far Eastern Scientific Center of Physiology and Pathology of Respiration SB of RAMS, 95A, Gorky str., 675000, Blagoveshchensk, Russian Federation E-mail: Lucencomt@mail.ru; Phone: 8 -416-2-52-2922

Published: September 24, 2013

Abstract: 

Chronic cytomegalovirus (CMV) infection in pregnant women is accompanied by the accumulation of large amounts of the circulating immune complexes (CIC) in the peripheral blood. On reaching the placental villous syncytiotrophoblast, the CIC induce a concentration of lysosomes of the syncytiotrophoblast cytosol on the outer membrane of the fetoplacental barrier. Contact between the circulating CIC and the lysosomes on the outer syncytiotrophoblast membrane triggers the release and expression, on its surface, of acidic phosphomonoesterase, which leads to lipid peroxidation and damage to the outer syncytiotrophoblast membrane itself.

Keywords: 
chronic cytomegalovirus infection; pregnancy; lysosomes; syncytiotrophoblast; circulating immune complexes.
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Int J Biomed. 2013; 3(3):174-176. © 2013 International Medical Research and Development Corporation. All rights reserved.