Clinical Predictors of Resistance to Antidepressant Therapy

CLINICAL RESEARCH
Nargiza F. Yadgarova*, Nazira I Khodjaeva PhD, ScD

Tashkent Medical Academy, Tashkent, Uzbekistan

*Corresponding author: Nargiza F, Yadgarova, Department of Psychiatry, Tashkent Medical Academy. 2, Faroby str., 100109, Tashkent, Uzbekistan. E-mail: 7619911@mail.ru

Abstract: 

The aim of the study was to identify the predictors of treatment-resistant depression (TRD) with positive affectivity. The article presents the results of the examination of 96 patients with TRD. The studied patients were divided into two groups: in the first group consisted of patients with TRD having positive affectivity (n=59), in the second group consisted of patients with curable depression (n=37). The study had shown the highest correlation value of such factors as frequency of depressive episodes, duration and severity of the first depressive episode, the quality of remission after the first depressive episode.

Keywords: 
predictors of treatment-resistant depression; positive affectivity; frequency and duration of the episode; quality of remission.
References: 
  1. Balashov AM. Issues of resistance to the pharmacotherapy. Journal of neurology and psychiatry named after Korsakov 2009; 1(109):90-91.
  2. Bosworth HB, Hays JC, et al. Psychosocial and clinical predictors of unipolar depression outcome in older adults. Int J Geriatr Psychiatry 2002; 17:238-246.
  3. Ferreri M, Lavergne F, Berlin L, Payan L, Puech AJ. Benefits from mianserin augmentation of ftuoxetine in patients with major depression non-responders to ftuoxetine alone. Acta Psychiatr Scand 2001; 103:66-72.
  4. Mclartin ТК. Sokcro TP. Severity and comorbidity predict episode duration and recurrence of DSM-IV major depressive disorder. J Clin Psychiatry 2004; 65:810-19.

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Int J Biomed. 2012; 2(4):279-281. © 2012 International Medical Research and Development Corporation. All rights reserved.