Bukovinian State Medical University, Chernivtsi, Ukraine
Corresponding author: Professor Tamila V. Sorokman, PhD, ScD, Head of Pediatrics and Medical Genetics Department, Bukovinian State Medical University, 5, Kochubeya str. 58003, Chernivtsi, Ukraine. Tel.: 00380506642667, Fax: 00380372553754. E-mail:email@example.com
The genetic structure of Helicobacter in children with gastroduodenal pathology and the regional distribution of the pathogenic genes of Helicobacter pylori (CagA and VacA) were established. Almost all the Helicobacter pylori (HP) strains showed the presence of gene toxicity (tox+) of 71.7%. The spectrum of toxigenic HP genes shows the following distribution: CagA+ defined in 70 persons (81.3%), VacA + determined in 62 individuals (72.1%). In this study, the specific distribution patterns of the causative agent of the pathogenic genotypes are established in the various diseases of the gastroduodenal region in children, and the comparative topological characterization of the bacterial inoculation of the gastrointestinal tract with Helicobacter pylori of different genotypes is presented.
- Sorokman T, Andriychuk D, Sokolnik S, Kutsobina N, et al. Modern views on aetiopathogenesis of gastric and duodenal disease of children. Child’s health 2009 Mar; 2(17): 85-88.
- Sabbi T, Dall'Oglio L, De Angelis P, Torroni E, Colistro F, Azzolina M, Santoni A, Di Ciommo V, Benedetto M. Utility of a stool antigen test to detect the incidence of helicobacter pylori infection and familial and community enviromental risk factors for this infection in pediatric age. Pediatr Med Chir 2012 Mar-Apr; 34(2):89-95.
- Uyanikoğlu A, Danalioğlu A, Akyüz F, Ermış F, Güllüoğlu M, Kapran Y, et al. Etiological factors of duodenal and gastric ulcers. Turk J Gastroenterol 2012 Apr; 23(2):99-103.
- Karlsson A, Ryberg A, Nosouhi Dehnoei M, Borch K, Monstein HJ. Association between cagA and vacA genotypes and pathogenesis in a Helicobacter pylori infected population from Southeastern Sweden. BMC Microbiol 2012 Jul 2; 12(1):129.
The fully formatted PDF version is available.
Int J Biomed. 2012; 2(4):285-287. © 2012 International Medical Research and Development Corporation. All rights reserved.