A Prospective Observational Study of the Correlation between Obesity and the Autonomic Nervous System
Rural Medical College, Loni, Maharashtra, India
*Corresponding author: Kiran D. Thorat, MBBS, MD, Assistant professor, Dept. of Physiology, Rural Medical College, Loni, Maharashtra, India. Address: Yashodip, 8 – Samarth Nagar, Tapovan Link Road, Opposite Karma Heights, Dwarka, Nasik, Maharashtra, India. PIN – 422011. E-mail: firstname.lastname@example.org. Mobile: 91-9960-339506; 91-8007-784122
Background: As the ANS is involved in energy metabolism and the regulation of the cardiovascular system, people with idiopathic obesity can be considered to suffer an alteration in their autonomic nervous system.
Aim: To correlate the BMI with cardiovascular autonomic functions.
Objectives: To correlate three different sample groups of BMI in relation to their Cardiovascular Sympathetic and Parasympathetic functions.
Study design: This was a prospective observational study.
Type of data: This was the Primary Data.
Population: Data has been collected from Pravara Rural Hospital Loni, Maharashtra, India.
Sample size: 69 completely healthy male subjects (not having any major illness or chronic addiction) were selected for the study. All the subjects were evaluated using «CANWIN» cardiac autonomic neuropathy analyzer; windows based cardiac autonomic neuropathy analysis system with interpretation.
Statistical analysis: Descriptive statistics was done and presented using tables and graphs, including mean values for continuous data to discuss the results. Correlations of outcome parameters were calculated with significance test. Statistical software SPSS, version16.0 was used for analysis.
Results: Orthostatic hypotension and Handgrip test (increase in DBP) were more pronounced in Group III. Valsalva ratio test showed very weak negative correlation in group I and very weak positive correlation in Group II and III.
Conclusion: Increased sympathetic activity and to some degree decreased Parasympathetic activity were found in correlation with the obesity. The study concluded that a more marked influence of obesity on activation of the sympathetic nervous system was observed.
1. Çolak R, Dönder E, KKaraglu A, Ayhan O, Yalniz M. Obesity and the activity of the autonomic nervous system. Turk J Med Sci 2000; 30:173–176.
2. Hirsch J, Leibel RL, Mackintosh R, Aguirre A. Heart rate variability as a measure of autonomic function during weight change in humans. Am J Physiol 1991; 261:1418-23.
3. Arone LJ, Mackintosh R, Rosenbaum M, Leibel RL, Hirsch J. Autonomic nervous system activity in weight gain and weight loss. Am J Physiol 1995; 269: 225-5.
4. Bray GA. Autonomic and endocrine factors in the regulation of energy balance. Fed Proc 1986; 45: 1404-10.
5. Landsberg L, Young JB. The role of the sympathoadrenal system in modulating energy expenditure. Clin Endocrinol Metab 1984;13: 475-99.
6. Bray GA. Integration of energy intake and expenditure in animals and man: the autonomic and adrenal hypothesis. Clin Endocrinol Metab 1984; 13: 521-46.
7. Peterson HR, Rothschild M, Weinberg CR, Fell RD, McLeish KR, Pfeifer MA. Body fat and the activity of the autonomic nervous system. N Engl J Med 1988; 28:1077-83.
8. Eikelis N, Schlaich M, Aggarwal A, Kaye D, Esler M. Interactions between leptin and the human sympathetic nervous system. Hypertension 2003; 41: 1072–1079.
9. Haynes W G, Morgan D A, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997; 100: 270–278.
10. Popruk S, Tungtrongchitr R, Pongpaew P, et al. Relationship between soluble leptin receptor, leptin, lipid profiles, and athropometric parameters in overweight and obese Thai subjects. J Med Assoc Thai 2005; 88:220–227.
11. Tang-Christensen M, Havel PJ, Jacobs RR, Larsen PJ, Cameron JL. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab 1999; 84: 711–717.
12. Reinehr T, Kratzsch J, Kiess W, Andler W.) Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children. Int J Obes Relat Metab Disord 2005; 29: 1230–1235.
13. Kaufman CL, Kaiser DR, Steinberger J, Kelly AS, Dengel DR. Relationships of cardiac autonomic function with metabolic abnormalities in childhood obesity. Obesity 2007; 15:1164-1171.
14. Riva P, Martini G, Rabbia F, Milan A, Paglieri C, Chiandussi L, Veglio F. Obesity and autonomic function in adolescence. Clin Exp Hypertens 2001; 23: 57-67.
15. Laederach-Hofmann K, Mussgay L, Ruddel H. Autonomic cardiovascular regulation in obesity. Journal of Endocrinology 2000; 164: 59–66.
Int J Biomed. 2011; 1(3):128-131. © 2011 International Medical Research and Development Corporation. All rights reserved.