TP53 Arg72Pro Gene Polymorphism in Patients with Malignant Head and Neck Tumors
Tashkent Medical Academy, Tashkent, Uzbekistan
Several studies have shown that the Arg72Pro TP53 gene polymorphism is associated with an increased risk of malignancies. The aim of this study is to investigate the distribution of the genotypes of Arg72Pro TP53 gene polymorphism in patients with malignant tumors of the head and neck (MTHN). The study involved 117 patients including 90 males and 27 females, of mean age 54.3±8.6, having MTHN. The control group consisted of 70 Uzbek volunteers (mean age 51.0±6.2 years) without malignant tumors. The frequency of the distribution of the genotypes of Arg72Pro TP53 polymorphism in patients having MTHN included Arg/Arg - 0.1, Arg/Pro - 0.68, Pro/Pro - 0.20; χ2=99.308, p=0.000. In healthy volunteers the ratio of Arg/Arg: Arg/Pro: Pro/Pro was found to be 0.27:0.52:0.20; χ2=21.57, p=0.000. The heterozygous genotype was dominant in the patients with MTHN, as well as those in the control group. However, the findings were significantly higher in the study group, viz., 0.68 as against 0.52 in the control group (p=0.03). The homozygous genotype Arg/Arg was rarely encountered in the patients, viz., 0.11 in the study group compared with 0.27 in the control group (p=0.005). The risk of being an MTHN carrier was found to be associated with the polymorphic marker gene TP53, and particularly, with the accumulation of the Arg/Pro genotype [OR: 1.93 (95% CI: 1.05-3.55)], while reducing the frequency of the Arg/Arg genotype [OR: 0.34 (95% CI: 0.15-0.73)].
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