¹Stavropol State Medical Academy, Stavropol, Russian Federation
²Stavropol Krai Clinical Dermato-Venereological Dispensary, Stavropol, Russian Federation
³Stavropol Krai Clinical Consultative and Diagnostic Center, Stavropol, Russian Federation
*Corresponding author: Azret Kh. Kaziyev, PhD, ScD, Associate Professor, Department of Microbiology, Stavropol State Medical Academy, 92, Shpakovskaya str., apt. 5, Stavropol, Stavropol Krai, Russian Federation. Tel: 7-918-8830713 E-Mail: email@example.com
Currently, there is an alarming increase in the syphilis rates accompanied by a proportional rise in the incidence of latent forms of the disease among the population of several countries. Latent syphilis considerably delays timely detection, diagnosis and, therefore, the specific early treatment of patients. In 2007, the proportion of latent forms of syphilis in the Russian Federation amounted to 49.7% of all reported syphilis cases . Importantly, it is very important to note latent syphilis was found in each of the 4 cases of HIV-infected patients. The absence of clinical manifestations in patients with this type of syphilis is of great scientific and practical interest, and only serological examination is seen to contribute to the diagnosis of this disease. The properties of the Treponema pallidum (TP) and the state of immunity in the infected person are well known to be the main factors influencing the development of the pathology. However, studying the properties of the causative agent of syphilis is quite impossible because modern strains of TP are absent. In this connection, the relevance of studying the characteristics of protective mechanisms in the latent forms of syphilis is obvious. In our study, we investigated the amount of T-lymphocytes and their subpopulations, which are CD2, CD3, CD4, CD8, CD16, CD19 and CD25. The study identified a significant deficiency of CD4+ and suppressive/cytotoxic T cells, as well as significantly low levels of CD25, which is important in stimulating the proliferation of T and NK cells.
- Zaitsev VM, Liflyandsky VG, Marinkin VI. Applied Medical Statistics. St. Petersburg, 2003.
- Levashova TV. Method for determination of minor subpopulations of T-lymphocytes with alpha/beta and gamma/delta T-cell receptor. Abstracts of the Ninth All-Russian Medical and Biological Conference of Young Researchers "Man and his health". Moscow, 22 April 2006. p 93-96.
- Levashova TV, Miroshnichenko IV. Double-negative T cells in diseases associated with inflammation. Materials of the II All-Russian Scientific-Practical Conference "Society, State, and medicine for the elderly and persons with disabilities". Moscow, September 2005. p 62-63.
- Sergeenko VI, Bondarev IB Mathematical statistics in clinical trials. Moscow: GEOTAR-Media, 2006. p 186-194.
- Khaitov RM Immunology. Moscow: GEOTAR-Media, 2006.
- Chebotarev VV. Syphilis. Stavropol, 2010.
- Chereshnev VA, Patrusheva NB, Beykin YaB, et al. Syphilis: the immune system and laboratory diagnosis. Yekaterinburg: Ural Division of RAS, 2006. p 25-81.
- Cherinikh TV, Kashkin SV, Zaitseva GA, Mamaeva TA. Character immunological changes in patients with syphilis with severe clinical manifestations. Abstracts of the 3rd All-Russian Congress of Dermato-venereology. Kazan, 2009; S.97.
The fully formatted PDF version is available.
Int J Biomed. 2012; 2(1):38-40. © 2012 International Medical Research and Development Corporation. All rights reserved.