Impact of Intra-Extracranial Hemodynamics on Cerebral Ischemia by Arterial Hypertension (Part 1)
Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
*Corresponding author: Prof. Alexander Y. Vasilyev, PhD, ScD, Head of Radiology Department, Moscow State University of Medicine and Dentistry, 15 Aviaconstructor Mil str., housing 1, apt. 70, 109431, Moscow, Russian Federation. Tel: 7-495-6110177, E-mail: email@example.com
The present study was conducted to examine the interaction of biochemical parameters within the blood flow, their effect on the cerebral blood flow, as well as the mechanisms of cerebral ischemia by stable arterial hypertension. The hemodynamics and biochemical indicators of cerebral blood flow without the additives of the extracranial blood were obtained by the catheterization method via a probe wedged at the level of the bulb of the superior jugular vein. Sampling of the arterial blood was done in the thoracic aorta. Correlation and factor analysis of the relationship of the biochemical substances within the blood flow, and of the hemodynamic indicators of the cerebral inflow and outflow of blood were conducted by stable arterial hypertension compared with similar data of the control group. The differences thus identified led to the conclusion that by stable arterial hypertension, there is a loss of the homeostatic control of the factors determining the rheological and thrombogenic properties of the blood involved in the formation of cerebral ischemic events.
1. Aner L. Pial arterial reactions to hyper- and hypocapnia: a dynamic experimental study in cats. Eur Neurol 1978; 17(6):351-362.
2. Cameron JR, Caronna J. The effect of local changes in potassium and bicarbonate concentration on hypothalamic blood flow in the rabbit. J Physiol (Gr.Brit.)1976; 262(2):415-430.
3. Ernst E. Fibrinogen an independent cardiovascular risk factor. J Ing Mod 1990; 227:365-372.
4. Guria GT. Macroscopic structure formation in blood dynamics in the light of the theory of unbalanced structures. A dissertation for the degree of Doctor of Physical and Mathematical Sciences. Moscow. Moscow State University, 2002.
5. Kety SS. Cerebral circulation. In: Handbook of physiology; Washington 1960 (5), 1751.
6. Lassen NA, Christensen MS. Physiology of cerebral blood flow. Brit J Anaesth 1976; 48:719- 734.
7. Rossanda M, Sganzerla EP. Acid-base and Gas Tension on Measurements in Cerebrospinal fluid. Brit J Anaesth 1976; 48(8):753-760.
8. Tranqui-Poit L, Marder VJ, Suscillon M, Budzynski AZ, Hurdly-Clergeon J. Electron microscopic studies of plasmic degradation products of fibrinogen. Implication for disulfide structure of fibrinogen. Biochem Biophys Acta 1975; 400 (2):189-199.
The fully formatted PDF version is available.
Int J Biomed. 2012; 2(2):89-95. © 2012 International Medical Research and Development Corporation. All rights reserved.