Impact of Intra-Extracranial Hemodynamics on Cerebral Ischemia by Arterial Hypertension (Part 2)
Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
*Corresponding author: Prof. Alexander Y. Vasilyev, PhD, ScD, Head of Radiology Department, Moscow State University of Medicine and Dentistry, 15 Aviaconstructor Mil str., housing 1, apt. 70, 109431, Moscow, Russian Federation. Tel: 7-495-6110177 E-mail: firstname.lastname@example.org
The association between hemodynamic and biochemical parameters of cerebral blood flow have been studied in man, using mathematical methods of statistics. The values have been obtained through catheterization using a probe jammed at the level of the bulb of the superior jugular vein. Relationships with central hemodynamic parameters have been evaluated, including the right atrium, the right ventricle, and the left ventricle, as well as with pressure and biochemical values of the arterial bed. Data have been acquired in patients with stable arterial hypertension. Analysis of all relationship between hemodynamic and biochemical parameters has shown that the uniform hemodynamic zone: Sin.P.–SJV–SEV–the right atrium, normally participates in regulation of gaseous exchange in the human brain depending on the minimum pressure on the way of outflow from the brain. In stable arterial hypertension, this type of regulation is lost. On the basis of the results of this study, it has been concluded that blood viscosity is normally a primary controlled parameter of homeostasis. In stable arterial hypertension, homeostatic control of factors determining rheological and thrombogenic properties of blood, as well as participating in the development of brain ischemic conditions is lost. This increases risk of disturbances in central hemodynamics.
1.Baevsky RM, Bondarchul VI, Chernyshov MK. Temporal organization of cardiac rhythm in terms of evolution. In the book: Problems of comparative cardiology (Syktyvkar), 1979. p 4. [in Russian].
2. Gebel GY, Kruglov AG, Utkin VN, Golostenova LM, Dasaev AN, Ignatov NG. Total gaseous pressure in blood of the vessels of outflow from the cardiac ventricular block in human. 6th All-Russian scientific forum “Keys to diagnostics and treatment of cardiovascular diseases”. Moscow, IRC, January 20 -23, 2004. p 116-122. [in Russian].
3. Kuzmina NB, Drogaicev AD. Formation of blood flow in the cavity of the left ventricle. In book: Cardiac physiology. Series: Guidance in physiology, 1980. p 212-214. [in Russian].
4. Lightfoot A. Transport phenomena in live systems. Biomedical aspects of momentum and mass transport. Moscow: Mir, 1977. p 520. [in Russian].
5. Levtov VA, Regirer SA, Shadrina NH. Hemorheology. Moscow: Medcine, 1982. p 270. [in Russian].
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Int J Biomed. 2012; 2(2):96-101.© 2012 International Medical Research and Development Corporation. All rights reserved.