The Relationship between the Epidermal Melanocytes, Langerhans Cells and Epidermal Cambial Cells
Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Moscow, Russian Federation
*Corresponding author: Tatyana M. Yavisheva, PhD, ScD, Leading Researcher, Blokhin Cancer Research Center of Russian Academy of Medical Sciences, 29/33, Building «B», Valovaya str., apt. #50, 115054, Moscow, Russian Federation. Tel: 7-905-7354590 (mobile). E-mail: email@example.com
The epidermis of 60 mice ears is investigated in this study. The proliferative activity of the epidermal basal cells over 24h was observed to occur in two active phases (AP) and 2 passive phases (PP). The AP phase in turn consists of two subphases. Subphase 1, the longer of the two, is a proliferation of the descendants of the cambial cells; Subphase 2, is very short, involving a proliferation of the cambial cells. The proliferation of the latter occurs at the time of transition of the AP to PP; therefore, the number of melanocytes and Langerhans cells getting involved in the epidermal cambial cell division, increases in the epidermis. The number of Langerhans cells almost doubles compared with the melanocytes, as the latter are gradually transformed into epidermal basal cells.
1.Merad M, Manz M, Karsunky H. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 2002; 3:1135-1141.
2.Semkin V. Morphofunctional changes of deferens at ageing. Klinicheskaya gerontologiya 2001; 9:37-31. [in Russian].
3.Bauer J, Bahmer F, Worl J. A strikingly constant ratio exists between Langerhans cells and other epidermal cells in human skin. A stereologic study using the optical dissector method and the confocal laser scanning microscope. J Invest Dermatol 2001; 116:313-318.
4.Yavisheva T, Yagubov A. Quantitative morphology of mouse cornea multilayered epithelium basal layer cells and human lung cancer. Ontogenez 1996; 27:95-99. [in Russian].
5.Yavisheva T, Shcherbakov S. Characteristic features of proliferation and differentiation of cambial and daughter cells in morphofunctional zones in normal epithelium and cancer in age aspect. Uspekhi gerontologii 2009; 22:605-613. [in Russian].
6.Hoath S, Leahy D. The organization of human epidermis: functional epidermal units and phi proportionality. J Invest Dermatol 2003; 121:1440-1446.
7.Chorro L, Sarde A, Li M. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expantion of the epidermal LC network. J Experimental Medicine 2009; 206:3089-3100.
8.Romani N, Holzmann S, Tripp C. Langerhans cells – dendritic cells of the epidermis. Apmis 2003; 111:725-740.
9.Chagin V, Rozanov Yu, Tomilin N. Multiple retardation of DNA synthesis during S-phase of cell cycle: research by a method of flow cytometry. Doklady Akademii Nauk 2004; 394:123-126. [in Russian].
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