The Clinical Role of Nitric Oxide and L-arginine in Asthma

CLINICAL RESEARCH
A.L. Alyavi, PhD, ScD; S.A. Bazarova; G.S. Dzhambekova, PhD; G.M. Каsimova, PhD

Republican Specialized Scientific-Practical Medical Center of Therapy and Medical Rehabilitation; Tashkent, Uzbekistan

*Corresponding author: Sayyora A. Bazarova, Republican Specialized Scientific-Practical Medical Center of Therapy and Medical Rehabilitation. Tashkent, Republic of Uzbekistan. Tel: 998946531358. E-mail: d-sayyorik@mail.ru

Abstract: 

NO is an important biological marker in the activity of the inflammatory process and endothelial dysfunction in bronchopulmonary diseases. Endothelial dysfunction appears as a primary element for vessel wall lesion that causes formation of the cardiovascular effects in asthma. Cardiovascular effects are considered as system displays of various diseases, among which endothelial dysfunction appears as the primary element of a vessel wall lesion. Studying NO metabolites and L-arginine content plays an important role for required correction in the respiratory system endothelium. 

Keywords: 
nitric oxide; L–arginine; asthma; endothelial dysfunction. References
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IJBM 2014; 4(4) Suppl 1:S23-S26. © 2014 International Medical Research and Development Corporation. All rights reserved.