The Role of Immunological Mechanisms in Physiological Pregnancy and the Consequences of Disturbing Them during in vitro Fertilization

Eduard A. Kashuba, Yuliya S. Chekhova, Svetlana V. Solovyova, Tatiana G. Drozdova, Daria D. Bekina

International Journal of Biomedicine. 2020;10(2):116-119.
DOI: 10.21103/Article10(2)_OA5
Originally published June 15, 2020.


We observed the immunologic status of clinically healthy women and women with tuboperitoneal infertility during the planning and first trimester of pregnancy. The markers of unsuccessful in vitro fertilization (IVF) attempts were also identified. No pathological anomalies were noted in the clinically healthy women before and after conception. The changes in the immune system of infertile women who underwent IVF were different from the women who had physiologic pregnancy. Identification of these changes could help to guide preventive measures while preparing for IVF and during the IVF procedure.

pregnancy • infertility • in vitro fertilization • immunologic status

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Received December 5, 2019.
Accepted February 6, 2020.
©2020 International Medical Research and Development Corporation.