Experimental Substantiation for the Effectiveness of Gastrostomy using a Polypropylene Endoprosthesis Based on a Comparative Morphological Assessment of the State of the Hollow Organs of the Gastrointestinal Tract

Sergey N. Shurygin, Alexey G. Vaganov, Archil S. Tsulaya, Dmitriy A. Volkov, Ilya V. Sazhin, Aleksandr N. Alimov, Leonid V. Safonov, Sarkis A. Asratyan

International Journal of Biomedicine. 2020;10(3):251-256.
DOI: 10.21103/Article10(3)_OA10
Originally published September 10, 2020


The article discusses the morphological changes in the mucous membrane of the stomach, duodenum, small intestine and large intestine after gastrostomy performed by the proposed original method of using an implant, in comparison with the classical Witzel gastrostomy and Depage-Janeway gastrostomy using the GIA stapler in laboratory animals (rabbits). Morphological changes were studied on Days 10 and 20 after surgery. It has been shown that gastrostomy causes adaptive-compensatory changes of a various nature, developing along the conveyor principle (along the passage of the food bolus), the morphological picture of which is represented by lymphohistiocytic infiltration and hemocirculatory disorders of a congested origin. The study revealed that the proposed original method of gastrostomy is characterized by a minimal damaging effect on the LGT, in comparison with the studied analogues.

gastrostomy • gastrointestinal tract • morphology • polypropylene mesh
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Received July 22, 2020.
Accepted August 24, 2020.
©2020 International Medical Research and Development Corporation.