Characterization of the Corpus Callosum Morphology in Healthy Sudanese Adults using MRI

Alnour Badawi, Caroline Edward Ayad, Mogahid M.A. Zidan, Ikhlas Abdalaziz, Batil Alonazi, Mustafa Z. Mahmoud, Mohamed Yousef, Lubna Bushara, Mohamed Adam

International Journal of Biomedicine. 2020;10(3):215-220.
DOI: 10.21103/Article10(3)_OA3
Originally published September 10, 2020


The aim of this study was to characterize the morphological differences of the corpus callosum (CC) concerning gender- and age-related variations, and establish reference values of the CC measurements for Sudanese participants using magnetic resonance imaging (MRI).
Materials and Results: MRI scans from 196 males and 189 females, ranging in age from 18 to 84, were reviewed. Only MRI studies without pathological findings were included in the analysis. The following measurements were done: the longitudinal dimensions of the brain, CC, the genu of CC, the splenium of CC, as well as craniocaudal height of the body of CC. Callosal longitudinal dimensions were measured using the Witelson division method. The longitudinal dimension of the genu was found to be larger in females (11.12±1.54 mm) than in males (10.73±1.75 mm) (P=0.021). The longitudinal dimension of the brain was greater in males (161.6±7.2 mm) than in females (159.3±7.6 mm) (P=0.002). There was a weak statistically significant direct correlation between age and CC ratio (r=0.271, P<0.05).
Conclusion: The results revealed that only the genu length showed sexual dimorphism and was larger in females than in males. This study showed variabilities regarding the CC dimensions in Sudanese participants compared to the Caucasian, Indian, and Japanese population.

corpus callosum • gender • age • magnetic resonance imaging • Sudanese population
  1. Paul LK, Brown WS, Adolphs R, Tyszka JM, Richards LJ, Mukherjee P, Sherr EH. Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity. Nat Rev Neurosci. 2007;8(4):287-299. doi:10.1038/nrn2107
  2. Mourgela S, Anagnostopoulou S, Sakellaropoulos A, Gouliamos A. An MRI study of sex-and age-related differences in the dimensions of the corpus callosum and brain. Neuroanatomy. 2007;6(1):63–65.
  3. Snell RS. Clinical neuroanatomy, 7th Edition. Philidelphia: Lippincott Williams & Wilkins; 2009.
  4. Cignini P, D'emidio L, Padula F, Girgenti A, Battistoni S, Vigna R, Franco R, Rossetti D, Giorlandino M, Giorlandino C. The role of ultrasonography in the diagnosis of fetal isolated complete agenesis of the corpus callosum: a long-term prospective study. J Matern Fetal Neonatal Med. 2010;23(12):1504-1509. doi:10.3109/14767051003678101
  5. Keshavan MS, Diwadkar VA, Harenski K, Rosenberg DR, Sweeney JA, Pettegrew JW. Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia. J Neurol Neurosurg Psychiatry. 2002;72(6):757-760. doi:10.1136/jnnp.72.6.757
  6. Zidan MM, Abdalaziz I, Elnour AM, Alghamdi SS, Mahmoud MZ, Ali WM, Abd-Elgyoum AM. Prevalence and clinical importance of the incidental findings in brain MRI examinations. Bioscience Research. 2020;17(2):888–893.
  7. Corballis MC, Finlay DC. Interhemispheric visual integration in three cases of familial callosal agenesis. Neuropsychology. 2000;14(1):60-70.
  8. Thompson PM, Giedd JN, Woods RP, MacDonald D, Evans AC, Toga AW. Growth patterns in the developing brain detected by using continuum mechanical tensor maps. Nature. 2000;404(6774):190-193. doi:10.1038/35004593
  9. Mohammadi MR, Zhand P, Mortazavi Moghadam B, Golalipour MJ. Measurement of the corpus callosum using magnetic resonance imaging in the north of Iran. Iran J Radiol. 2011;8(4):218-223. doi:10.5812/iranjradiol.4495
  10. Gupta T, Singh B, Kapoor K, Gupta M, Kochhar S. Normative data of corpus callosal morphology in a North-West Indian population- an autopsy and MRI study. JNMA J Nepal Med Assoc. 2009;48(173):46-51.
  11. Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain. 1989;112 ( Pt 3):799-835. doi:10.1093/brain/112.3.799
  12. Takeda S, Hirashima Y, Ikeda H, Yamamoto H, Sugino M, Endo S. Determination of indices of the corpus callosum associated with normal aging in Japanese individuals. Neuroradiology. 2003;45(8):513-518. doi:10.1007/s00234-003-1019-8
  13. Suganthy J, Raghuram L, Antonisamy B, Vettivel S, Madhavi C, Koshi R. Gender- and age-related differences in the morphology of the corpus callosum. Clin Anat. 2003;16(5):396-403. doi:10.1002/ca.10161
  14. Bermudez P, Zatorre RJ. Sexual dimorphism in the corpus callosum: methodological considerations in MRI morphometry. Neuroimage. 2001;13(6 Pt 1):1121-1130. doi:10.1006/nimg.2001.0772
  15. Gupta T, Singh B, Kapoor K, Gupta M, Kochhar S. Age and sex related variations in corpus callosal morphology. Nepal Med Coll J. 2008;10(4):215-221.

Download Article
Received August 4, 2020.
Accepted September 2, 2020.
©2020 International Medical Research and Development Corporation.