Effect of Wrist Tapping on Interhemispheric Coherence in Patients with Juvenile Myoclonic Epilepsy

Ekaterina A. Narodova, Natalia A. Shnayder, Vladislav E. Karnaukhov, Olesya D. Bogomolova, Kirill V. Petrov, Valeriya V. Narodova

International Journal of Biomedicine. 2021;11(1):73-77.
DOI: 10.21103/Article11(1)_OA12
Originally published March 5, 2021


The aim of this study was to assess the dynamics of interhemispheric coherence (IC) as an indicator of integration of different areas of the brain and their participation in the performance of certain functions before and after wrist tapping (WT), using the author's method in juvenile myoclonic epilepsy (JME).
Methods and Results: The study included 81 subjects of working age, including 51 clinically healthy volunteers (median age of 39[21;56] years) and 30 patients (median age of 27[23;38] years) with JME. Analysis of IC in the electrode pairs Fp1-Fp2, F3-F4, C3-C4, T3-T4 was performed using a computer encephalographic complex. A coherent EEG analysis was used to identify and evaluate the relationships between different areas of the brain. Based on the change in the coherence coefficients (CCs), the level of integrative activity of brain structures was quantified. In healthy volunteers, before and after WT, we observed a statistically significant decrease in CCs for the beta-1 band in the pairs Fp1-Fp2, F3-F4, and C3-C4 (P<0.05), while in the pair T3-T4, changes in CCs were not statistically significant (P>0.05). At the same time, a statistically significant decrease in CCs in the alpha band was found only in the frontal regions in the pairs Fp1-Fp2 and F3-F4 (P<0.05). No statistically significant changes were found in all the studied pairs in the theta band. When comparing CCs in JME patients in beta–1 and theta bands, before and after WT, we did not find statistically significant changes in CCs in all the studied electrode pairs.  However, in the alpha band, we found a statistically significant decrease in CCs in the frontal region in the F3-F4 (P=0.0038) and C3-C4 electrode pairs (P=0.034). The results of the study of interhemispheric integration showed statistically significant differences between patients with JME and the control group.
Conclusion: WT according to the author's method does not provoke the occurrence of interictal epileptiform discharges on the EEG and epileptic seizures in patients with JME. Coherent analysis showed positive changes in interhemispheric integrations of neurons in the beta–1 and alpha frequency ranges, mainly in the anterior hemispheres.

interhemispheric coherence • electroencephalography • epilepsy • wrist tapping
  1. Bate L, Gardiner M. Molecular genetics of human epilepsies. Expert Rev Mol Med. 1999;1999:1-22. doi: 10.1017/S1462399499001349.
  2. Wang L, Wu L, Wang Y, Li H, Liu X, Du X, Dong G. Altered Brain Activities Associated with Craving and Cue Reactivity in People with Internet Gaming Disorder: Evidence from the Comparison with Recreational Internet Game Users. Front Psychol. 2017;8:1150. doi: 10.3389/fpsyg.2017.01150
  3. Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, Martinez R, Hsu S, Fernandez MV, Cairns NJ. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Transl Psychiatry. 2018;8(1):265. doi: 10.1038/s41398-018-0319-z
  4. Wang Y, Berglund IS, Uppman M, Li TQ. Juvenile myoclonic epilepsy has hyper dynamic functional connectivity in the dorsolateral frontal cortex. Neuroimage Clin. 2019;21:101604. doi: 10.1016/j.nicl.2018.11.014  
  5. Ivanov LB. State of intra- and interhemispheric integration according to coherent EEG analysis in healthy children and in pathology. Proceedings of the international conference "Сlinical neuroscience: neurophysiology, neurology, neurosurgery." 5th Eastern European Conference "Epilepsy and Clinical Neurophysiology." Yalta-Gurzuf, June 01-10, 2003. Gurzuf; 2003:32-35. [in Russian]
  6. Kanda PAM, Anghinah R, Smidth MT, Silva JM. The clinical use of quantitative EEG in cognitive disorders. Dement Neuropsychol. 2009;3(3):195-203. doi: 10.1590/S1980-57642009DN30300004
  7.  Coan JA, Allen JJ. Frontal EEG asymmetry as a moderator and mediator of emotion. Biol Psychol. 2004;67(1-2):7-49. doi: 10.1016/j.biopsycho.2004.03.002
  8. Hattingen E, Lückerath C, Pellikan S, Vronski D, Roth C, Knake S, Kieslich M, Pilatus U. Frontal and thalamic changes of GABA concentration indicate dysfunction of thalamofrontal networks in juvenile myoclonic epilepsy. Epilepsia. 2014;55(7):1030-1037. doi: 10.1111/epi.12656
  9. Lin K, Jackowski AP, Carrete H Jr, de Araújo Filho GM, Silva HH, Guaranha MS, Guilhoto LM, Bressan RA, Yacubian EM. Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy. Epilepsy Res. 2009;86(2-3):138-145. doi: 10.1016/j.eplepsyres.2009.05.016
  10.  Kim SH, Lim SC, Kim W, Kwon OH, Jeon S, Lee JM, Shon YM. Extrafrontal structural changes in juvenile myoclonic epilepsy: a topographic analysis of combined structural and microstructural brain imaging. Seizure. 2015;30:124-131. doi: 10.1016/j.seizure.2015.06.009

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Received October 9, 2020.
Accepted November 18, 2020.
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