Men's Reproductive Health: Oxidative Stress and the Effectiveness of Antioxidant Therapy

Nadezhda A. Kurashova, Bair G. Dashiev, Ekaterina A. Kudeyarova, Lyubov I. Kolesnikova

 
International Journal of Biomedicine. 2021;11(3):333-336.
DOI: 10.21103/Article11(3)_RA4
Originally published September 9, 2021

Abstract: 

This review article surveys and summarizes the literature data concerning the problems of deterioration of the main indicators of men's reproductive health and the effectiveness of therapy with drugs with antioxidant properties.
The analysis of domestic and foreign literature confirms that oxidative stress (OS) accompanies and/or is one of the pathogenetic links in the development of many types of reproductive pathology in men.
The health status of the male population is influenced by the following factors: lifestyle, existing diseases, the state of the environment, and the genotype of the population. The interaction of several weak, but unidirectional, factors creates a high risk of developing male reproductive pathology. The polyetiological nature of fertility disorders in men causes certain difficulties in creating adequate methods of treating this pathology and causes multicomponent biocomplexes to appear on the pharmaceutical market that contain active substances that can affect the quality of the ejaculate.

Keywords: 
men • reproductive health • oxidative stress • infertility • antioxidant therapy
References: 

1. Kolesnikova LI, Kolesnikov SI, Kurashova NA, Bairova TA. [Causes and Factors of Male Infertility]. Vestn Ross Akad Med Nauk. 2015;(5):579-84. Russian. doi: 10.15690/vramn.v70.i5.1445. PMID: 26846084.. [Article in Russian].
2. Kurashova NA, Kudeyarova EA, Kuznetsova EO. [Parameters of Lipid Peroxidation and Antioxidant Protection in Men with Pathological Spermogram Variants]. Acta Biomedica Scientifica. 2019;4(1):14-18. doi: 10.29413/ABS.2019-4.1.2. [Article in Russian]
3. Kolesnikova LI, Kolesnikov SI, Kurashova NA, Osadchuk LV, Osadchuk AV, Dolgikh MI, Dashiev BG, Shantanova LN. Reproductive Health and Peculiarities of Lipid Peroxidation-Antioxidant Defense System in Men of the Main Ethnic Groups of the Baikal Region. Bull Exp Biol Med. 2015 Nov;160(1):32-4. doi: 10.1007/s10517-015-3091-6.
4. Kurashova NA, Dashiev BG., Dolgikh MI, Kolesnikovа LI. The Processes of Lipoperoxidation and Antioxidant Protection in Men with Different Variants of Spermograms. International Journal of Biomedicine. 2019;9(2):168-171. doi:10.21103/Article9(2)_OA18
5. Kolesnikova LI, Kurashova NA, Bairova TA, Dolgikh MI, Ershova OA, Natyaganova LV, Dashiev BG, Gutnik IN, Koroleva NV. Features of Lipoperoxidation, Antioxidant Defense, and Thiol/Disulfide System in the Pathogenesis of Infertility in Males, Carriers of Nonfunctional Variants of GSTT1 and GSTM1 Gene Polymorphisms. Bull Exp Biol Med. 2017 Jul;163(3):378-380. doi: 10.1007/s10517-017-3808-9. 
6. Kurashova NA, Dolgikh MI, Ershova OA, Gavrilova OA, Osipova EV, Dashiev BG, Bairova TA, Kolesnikov SI, Kolesnikovа LI. Associations of Polymorphic Variants of the Biotransformation Genes with the Components of the Glutathione System in Men with Infertility. International Journal of Biomedicine. 2017; 7(3): 226-230. doi: 10.21103/article7(3)_oa13
7. Kolesnikova LI, Kurashova NA, Osadchuk LV, Osadchuk AV, Dolgikh MI, Dashiev BG. Parameters of Pro- and Antioxidant Status in Ejaculate of Men of Fertile Age. Bull Exp Biol Med. 2015 Oct;159(6):726-8. doi: 10.1007/s10517-015-3059-6. 
8. Kurashova NA. Assessment of reproductive potential of men. Acta Biomedica Scientifica. 2014;(2):104-109. [Article in Russian]
9. Kirilenko EA, Onopko VF. [Oxidative stress and male fertility: a modern perspective on the problem]. Acta Biomedica Scientifica. 2017;2(114):102-108. [Article in Russian]
10. Garrido N, Meseguer M, Simon C, Pellicer A, Remohi J. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian J Androl. 2004 Mar;6(1):59-65.
11. Bazhenov IV, Filippova YeS. [Role of Oxidative Stress in the Male Infertility Pathogenesis]. Jeffektivnaja Farmakoterapija. 2018;29:50-58. [Article in Russian]
12. Baskaran S, Finelli R, Agarwal A, Henkel R. Reactive oxygen species in male reproduction: A boon or a bane? Andrologia. 2021 Feb;53(1):e13577. doi: 10.1111/and.13577. 
13. Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: A systematic review on evaluation and management. Arab J Urol. 2019 Apr 24;17(2):87-97. doi: 10.1080/2090598X.2019.1599624.
14. Lewis SE, Simon L. Clinical implications of sperm DNA damage. Hum Fertil (Camb). 2010 Dec;13(4):201-7. doi: 10.3109/14647273.2010.528823. 
15. Kuzmenko AV, Kuzmenko VV, Gyaurgiev TA. [The effectiveness of the Speroton complex in the management of male factor infertility]. Urologiia. 2018 Jul;(3):78-82. Russian. 
16. Agarwal A, Sekhon LH. The role of antioxidant therapy in the treatment of male infertility. Hum Fertil (Camb). 2010 Dec;13(4):217-25. doi: 10.3109/14647273.2010.532279. 
17. Nejmark AI, Klepikova II. [The use of the drug Selzinc plus in men with impaired fertility]. Andrology and Genital Surgery. 2013;4:77-80. [Article in Russian]
18. Kalinina SN, Koren'kov DG, Fesenko VN, Nazarov T N. [Prospects of systemic enzyme therapy for treatment of male immune infertility]. Andrology and Genital Surgery. 2020; 21(1):49-59. doi: 10.17650/2070-9781-2020-21-1-49-59. [Article in Russian]
19. Agarwal A, Finelli R, Selvam MKP, Leisegang K, Majzoub A, Tadros N, et al. A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility. World J Mens Health. 2021 Apr 1. doi: 10.5534/wjmh.210025. 
20. Liflyandsky VG. [Pathogenetic justification of dietary supplement testogenon™ for complex impact on men's reproductive system]. Andrology and Genital Surgery. 2015;16(2):61-65. [Article in Russian]
21. Nejmark AI, Klepikova II, Nejmark BA, Nozdrachev NA. [Androdoz use of the drug in men with impaired fertility]. Andrology and Genital Surgery. 2013;14(4):49–52. [Article in Russian]
22. Vladimirov, Yu. A. Free radicals in biological systems // Soros educational journal. 2000; 6(12): 13-19. doi: 0.1007/978-1-4612-0419-0_1
23. Korenkov DG, Pavlov AL, Kazimzade ED. [The influence of BESTFertil towards male reproductive function in idiopathic fertility]. Andrology and Genital Surgery.  2018;19(4):54-59. [Article in Russian].
24. Bozhedomov VA, Epanchintseva EA, Bozhe-Domova GE, Kamarina RA, Rokhlikov IM, Kamalov AA. [Hydrophilic and lipophilic nutrients for the treatment of male idiopathic infertility: a randomized, comparative, open-label, multicenter, prospective, controlled study]. Urologiia. 2021 Mar;(1):70-78. [Article in Russian].
25. Kopets R, Kuibida I, Chernyavska I, Cherepanyn V, Mazo R, Fedevych V, Gerasymov S. Dietary supplementation with a novel l-carnitine multi-micronutrient in idiopathic male subfertility involving oligo-, astheno-, teratozoospermia: A randomized clinical study. Andrology. 2020 Sep;8(5):1184-1193. doi: 10.1111/andr.12805. 
26. Wadhwa L, Priyadarshini S, Fauzdar A, Wadhwa SN, Arora S. Impact of Vitamin D Supplementation on Semen Quality in Vitamin D-Deficient Infertile Males with Oligoasthenozoospermia. J Obstet Gynaecol India. 2020 Feb;70(1):44-49. doi: 10.1007/s13224-019-01251-1. 
27. de Angelis C, Galdiero M, Pivonello C, Garifalos F, Menafra D, Cariati F, Salzano C, Galdiero G, Piscopo M, Vece A, Colao A, Pivonello R. The role of vitamin D in male fertility: A focus on the testis. Rev Endocr Metab Disord. 2017 Sep;18(3):285-305. doi: 10.1007/s11154-017-9425-0. 
28. Panner Selvam MK, Finelli R, Agarwal A, Henkel R. Proteomics and metabolomics - Current and future perspectives in clinical andrology. Andrologia. 2021 Mar;53(2):e13711. doi: 10.1111/and.13711. 
29. Garrido N, Meseguer M, Simon C, Pellicer A, Remohi J. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian J Androl. 2004 Mar;6(1):59-65. 

Download Article
Received May 10, 2021.
Accepted June 23, 2021.
©2021 International Medical Research and Development Corporation.