The Genotype Distribution of Human Papillomavirus among HIV-Infected Women Planning Pregnancy in Irkutsk, Russia

ORIGINAL ARTICLE
Elena Belyaeva, Eleva Genich, Olga Leshchenko

 
International Journal of Biomedicine. 2021;11(3):346-350.
DOI: 10.21103/Article11(3)_OA11
Originally published September 9, 2021

Abstract: 

The purpose of our research was to determine the detection frequency of 12 high-risk types of human papillomavirus (HPV) in women with human immunodeficiency virus (HIV) who are planning pregnancy and to assess the results of colposcopy and the state of the cervix in these women, depending on the presence of HPV.
Methods and Results: We examined 31 women with HIV infection who sought pregnancy-planning advice at Scientific Center for Family Health and Human Reproduction Problems in Irkutsk during 2014-2015. All HIV-infected women were tested for the presence of high-risk HPV DNA in the epithelium of the cervical canal by PCR. Material for cytological examination (PAP test) was collected during gynecological examination. PAP tests were assessed according to the Bethesda system. All changes were divided into two types: ASCUS and SIL, the last was in its turn divided into two categories: LSIL and HSIL.
The frequency of HPV detection in HIV-infected women planning pregnancy was 71%. HPV 16 was found in 16(51.6%) HIV-infected women and ranked first in frequency among 12 types of HPV. HPV 33 and HPV 35 were found in 15(48.4%) and 12(38.7%) HIV-infected women, respectively, and ranked the second and third in frequency among 12 HPV types. We compared abnormal colposcopy results in two groups of patients with HIV infection: Group 1 (n=22) included women with HPV and Group 2 (n=9) included women without HPV. ASCUS was detected in all patients of Group 1 (100%) and in 6(66.7%) women of Group 2. Two women (9.1%) from Group 1 were diagnosed with LSIL and 10(45.5%) women with HSIL.
Conclusion: HIV-infected women planning pregnancy and living in Irkutsk form a group at high-risk of HPV infection.

Keywords: 
human immunodeficiency virus • human papillomavirus • cervical cancer • cervical dysplasia
References: 
  1. Merli MG, Moody J, Mendelsohn J, Gauthier R. Sexual Mixing in Shanghai: Are Heterosexual Contact Patterns Compatible With an HIV/AIDS Epidemic? Demography. 2015 Jun; 52(3):919-42. doi: 10.1007/s13524-015-0383-4.
  2. Mukandavire C, Walker J, Schwartz S, Boily MC, Danon L, Lyons C, et al. Estimating the contribution of key populations towards the spread of HIV in Dakar, Senegal. J Int AIDS Soc. 2018 Jul;21 Suppl 5(Suppl Suppl 5):e25126. doi: 10.1002/jia2.25126.
  3. Coates TJ. The Fight Against HIV Is a Fight for Human Rights: A Personal Reflection. J Acquir Immune Defic Syndr. 2019 Dec 1;82 Suppl 2(2):S91-S93. doi: 10.1097/QAI.0000000000002165.
  4. Belyaeva EV, Pervushina OA, Timofeeva EV, Leschenko OYa. [The incidence of high-risk oncogenic types of human papillomavirus in HIV-infected women of reproductive age living in the Irkutsk area]. Infectious Diseases. 2015;3(4):57-61. [Article in Russian].
  5. Prevention gap report. 2016. http://www.unaids.org. Accessed May 11, 2021.
  6. Leshchenko O, Belyaeva E, Yershova O, Atalyan A, Timofeeva E. The frequency of human papilloma virus in women of reproductive age with infection. Journal of Lower Genital Tract Disease. 2017;21(2 S1): S39-S40.
  7. Kolesnikova LI, Kolesnikov SI, Darenskaya MA, Grebenkina LA, Timofeeva EV, Leshchenko OY, Vanteeva OA, Rashidova MA. [Evaluation of the pro- and antioxidant status of women with HIV or coinfection]. Ter Arkh. 2016;88(11):17-21.  doi: 10.17116/terarkh2016881117-21. [Article in Russian].
  8. Kolesnikova LI, Darenskaya MA, Rashidova MA, Sholokhov LF, Grebenkina LA, Leschenko OYa, Timofeeva EV. [Evaluation of oxidative stress in women with HIV mono- and coinfection]. Infectious disease. 2016;14(S1):138. [Article in Russian].
  9. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003 Jan;16(1):1-17. doi: 10.1128/cmr.16.1.1-17.2003.
  10. Bosch FX, de Sanjosé S. The epidemiology of human papillomavirus infection and cervical cancer. Dis Markers. 2007;23(4):213-27.
  11. WHO. Human papillomavirus (HPV) and cervical cancer. Available from: https://www.who.int/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer
  12. Looker KJ, Rönn MM, Brock PM, Brisson M, Drolet M, Mayaud P, Boily MC. Evidence of synergistic relationships between HIV and Human Papillomavirus (HPV): systematic reviews and meta-analyses of longitudinal studies of HPV acquisition and clearance by HIV status, and of HIV acquisition by HPV status. J Int AIDS Soc. 2018 Jun;21(6):e25110. doi: 10.1002/jia2.25110.
  13. Rocha-Brischiliari SC, Gimenes F, de Abreu AL, Irie MM, Souza RP, Santana RG, Gravena AA, de B Carvalho MD, Consolaro ME, Pelloso SM. Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women. Infect Agent Cancer. 2014 Feb 11;9(1):6. doi: 10.1186/1750-9378-9-6.
  14. Ford JH, Li M, Scheil W, Roder D. Human papillomavirus infection and intrauterine growth restriction: a data-linkage study. J Matern Fetal Neonatal Med. 2019 Jan;32(2):279-285. doi: 10.1080/14767058.2017.1378330.
  15. Sverdlova ES, Dianova TV, Sofina SS, Kulinich SI. [The etiopathogenetic approaches to diagnostics of cervix uteri diseases in immunocompromised women]. Siberian medical journal (Irkutsk). 2009;7:87-90. [Article in Russian].
  16. Martirosyan MM, Niauru DA, Stepanova YeV, Samarina AV. [Specificities of papilloma virus infection of cervix uteri in HIV-infected women in Saint-Petersburg]. HIV infection and immunosuppression. 2012;4(1):51-56. [Article in Russian].
  17. Shipulina OYu, Maksimova EG. [The prevalence of HPV infection of high oncogenic risk among men and women in Moscow and Irkutsk]. Proceedings of the  VIII All-Russian Scientific and Practical Conference with International Participation "Molecular Diagnostics-2014", March 18-20,  2014, Moscow. M.; 2014:198-200. [Article in Russian].
  18. Shipulina OYu, Popova AA, Kravchenko AV, Deulina MO, Dmitryukova MYu, Romanyuk TN. [Prevalence of high oncogenic risk genotypes of human papillomavirus in HIV-positive and HIV-negative females]. Infectious disease. 2016;14(4):26-30. doi: 10.20953/1729-9225-2016-4-26-30. [Article in Russian].
  19. Marochko KV, Artymuk NV. [Features of papillomavirus infection in human immunodeficiency virus-infected women]. Fundamental and clinical medicine. 2017;2(3):35-41. [Article in Russian].
  20. Joshi S, Babu JM, Jayalakshmi D, Kulkarni V, Divate U, Muwonge R, et al. Human papillomavirus infection among human immunodeficiency virus-infected women in Maharashtra, India. Vaccine. 2014 Feb 19;32(9):1079-85. doi: 10.1016/j.vaccine.2013.12.060.
  21. Camargo M, Soto-De Leon SC, Munoz M, Sanchez R, Peña-Herrera D, Pineda-Peña AC, et al. Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia. BMC Cancer. 2014 Jun 18;14:451. doi: 10.1186/1471-2407-14-451.
  22. Videla S, Darwich L, Cañadas MP, Paredes R, Tarrats A, Castella E, et al. HIV-HPV Study Group. Epidemiological data of different human papillomavirus genotypes in cervical specimens of HIV-1-infected women without history of cervical pathology. J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):168-75. doi: 10.1097/QAI.0b013e3181938e63.
  23. Dames DN, Blackman E, Butler R, Taioli E, Eckstein S, Devarajan K, et al. African Caribbean Cancer Consortium. High-risk cervical human papillomavirus infections among human immunodeficiency virus-positive women in the Bahamas. PLoS One. 2014 Jan 23;9(1):e85429. doi: 10.1371/journal.pone.0085429.
  24. Park EK, Cho H, Lee SH, Lee SG, Lee SY, Kim KH, et al. Human papillomavirus prevalence and genotype distribution among HIV-infected women in Korea. J Korean Med Sci. 2014;29(1):32-7. doi:  10.3346/jkms.2014.29.1.32

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Received May 14, 2021.
Accepted July 1, 2021.
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