Lipids Peroxidation Products in Young Men with Type 1 Diabetes Mellitus

ORIGINAL ARTICLE
Marina A. Darenskaya, Elena V. Chugunova, Sergey I. Kolesnikov, Natalya V. Semenova, Lyubov I. Kolesnikova

 
International Journal of Biomedicine. 2022;12(2):232-236.
DOI: 10.21103/Article12(2)_OA5
Originally published June 5, 2022

Abstract: 

The aim of this research was to assess the level of lipid oxidation products level and the antioxidant defense state in young male patients with type 1 diabetes mellitus (T1DM) depending on the disease duration.
Materials and Methods: A total of 57 men of young reproductive age (average age of 30.25±8.51 years) with T1DM and an unsatisfactory glycemic profile, depending on the disease duration, were divided into 2 groups. Group 1 included 29 men (average age of 27.69±6.92 years) with a T1DM duration <5 years (2.72±1.61 years) and HbA1c level of 11.37±2.74%. Group 2 included 28 men (average age of 32.89±9.28 years) with a T1DM duration ≥5 years (12.93±5.69) and HbA1c level of 10.19±2.18%). The control group consisted of 28 men of the same age (29.71±4.59 years).  Spectrophotometric/spectrofluorometric methods and enzyme immunoassay were used.
Results: We found a significant increase in the values of CDs (by 2.04 times, P<0.0001), KD and CT (by 2.38 times, P<0.0001), TBARs (by 1.17 times, P=0.001), SB (by 2.6 times, P<0.0001), and retinol (by 1.44 times, P<0.0001) in Group 1 compared to the control group. In Group 2, there was a statistically significant increase in the levels of CDs (by 2.59 times, P<0.0001), KD and CT (by 2.94 times, P<0.0001), TBARs (by 1.49 times, P=0.001), SB (by 3.27 times, P<0.0001), and retinol (by 1.4 times, P=0.001) compared to the control group. The differences between the two groups with different duration of T1DM were characterized only by the CDs level, which was increased in Group 2 patients with a T1DM duration of ≥5 years (by 1.27 times, P=0.048) compared to Group 1 patients with a T1DM duration of < 5 years.
Conclusion: LPO parameters can serve as additional laboratory markers that characterize the course of T1DM and can be used to develop potential prevention and therapy strategies.

Keywords: 
type 1 diabetes mellitus • men • diabetes duration • lipid peroxidation • antioxidant defense
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Received April 16, 2022.
Accepted May 24, 2022.
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