Clinical and Neurological Status in Patients with Mild Cognitive Impairment due to Chronic Cerebral Ischemia

CLINICAL RESEARCH
Yokudhon N. Madjidova, PhD, ScD¹*; Dildora Khaidarova²

¹Tashkent Medical Pediatric Institute, ²Tashkent Medical Academy; Tashkent, Uzbekistan

*Corresponding author:  Prof. Yokudhon N. Madjidova, MD, PhD. Head of Department of Neurology, Pediatric Neurology and Medical Genetics of Tashkent Medical Pediatric Institute. Tashkent, Uzbekistan. E-mail:  madjidova1@yandex.ru

Published: September 20, 2014. 

Abstract: 

The aim of our work was to study the neurological status and cognitive function in patients with stage I and II CCI, depending on its nature.

Material and Methods: The study included 302 patients (mean age 61.3±0.3 years; 165/54.6% men and 137/45.4% women) with stage I and II CCI. Clinical and neurological examination, study of cognitive function, and MRI were performed in all patients. The degree of cognitive defect was determined by the MMSE (Mini-Mental State Exam) test and the Bourdon test (visual perception and vigilance). All the subjects were categorized into two groups. Group 1 consisted of 133 patients with the amnestic type of MCI (AT-MCI); Group 2 consisted of 169 patients with the multifunction type of MCI (MT-MCI).

Results: The highest frequency of complaints of a cerebral nature was observed in Group 2 patients with MT-MCI compared to Group 1 patients with AT-MCI. It should be noted that memory impairment occurred in all patients in Group 1. The clinical-neurological examination revealed that the subjective complaints of a cerebral nature occurred significantly more frequently in Group 2 patients compared with Group 1 patients, except for the memory disorders, which prevailed in Group 1 patients with AT-MCI. With regard to the objective symptoms, the focal neurological symptoms occurred with equal frequency in both groups. It should be noted that the symptoms of the carotid region were more frequent in Group 2 patients and the symptoms of the vertebrobasilar region in Group 1 patients. The parameters of the cognitive function related to the concentration and stability of attention were less disturbed in patients with AT-MCI compared with the patients having the MT-MCI, and those parameters correlated with the parameters of the neurological focal symptoms.

Keywords: 
chronic cerebral ischemia (CCI); mild cognitive impairment (MCI); neurological status.
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Int J Biomed. 2014; 4(3):147-150. © 2014 International Medical Research and Development Corporation. All rights reserved.