¹ The I.I. Mechnikov Scientific-Research Institute of Vaccine and Sera, RAS; Moscow, Russia; ² Ulyanovsk State University; Ulyanovsk, Russia
*Corresponding author: Dmitry V. Pakhomov, PhD. Laboratory of vaccination and immunotherapy of allergic diseases, the I.I. Mechnikov Scientific-Research Institute of Vaccine and Sera, RAS; Moscow, Russia. E-mail: firstname.lastname@example.org
Published: December 3, 2015. DOI: 10.21103/Article5(4)_OA1
Vaccination against flu in the second and third trimesters of pregnancy with the use of Agrippal S1 is effective and meets the CPMP criteria. In our study, one month after vaccination, there was progress in the production of post-vaccination antibodies in protective values in pregnant women vaccinated in the third trimester of gestation. In neonates whose mothers had been vaccinated in the last trimester of pregnancy, there were also higher levels of protective antibodies to the flu A virus strains. Three months after childbirth, there were no significant differences in protective values of antibodies to all the strains of the flu virus in women of the compared groups. At the same time, in children born to women vaccinated in the third trimester of pregnancy, there was a significantly higher concentration of protective antibodies during the same period. Six months later, there were no transplacental antibodies in the protective values (³1:40) among the observed children. Comparison of the levels of protective titers of antibodies to the three strains of the flu virus in the mother-infant pairs, in all the periods of observation of the children, showed significantly lower values.
- Zaman K, Roy E, Arifeen SE, Rahman M, Raqib R, Wilson E, et al. Effectiveness of maternal influenza immunization in mothers and infants. N Eng J Med. 2008;359(15):1555–64.
- Steinhoff MC, Omer SB, Roy E, Arifeen SE, Raqib R, Altaye M, et al. Influenza immunization in pregnancy – antibody responses in mothers and infants. N Eng J Med. 2010;362(17)):1644-6.
- Zuccotti G, Pogliani L, Pariani E, Amendola A, Zanetti A. Transplacental antibody transfer following maternal immunization with a pandemic 2009 influenza A(H1N1) MF59-adjuvanted vaccine. JAMA. 2010;304(21):2360-1.
- Eick AA, Uyeki TM, Klimov A, Hall H, Reid R, Santosham M, et al. Maternal influenza vaccination and effect of influenza virus infection in young infants. Arch Pediatr Adolesc Med 2011;165(2):104-11.
- Order of the Ministry of Health and Social Development of the RF of October 2, 2009 No. 808n. On the Approval of the Order of Rendering Obstetric-Gynecologic Assistance. [Electronic resource]. http://www.bestpravo.ru/federalnoje/hj-dokumenty/l4v.htm
- Botina AV, Medvedeva TG, Neznanov NG. Ethical aspects of medical researches with the participation of women of reproductive age. Good Clinical Practice 2003;3:43-46.
- Good Clinical Practice. National Standard of the Russian Federation, GOSTR 52379-2005/ Moscow, 2005. [Electronic resource]. http://www.medtran.ru/rus/trials/gost/52379-2005.htm
- Recommendations on the Organization and Implementation of Vaccination of Pregnant Women and Maternity Patients against the Flu A Virus (Н1N1): Informational letter No. 15-4/3108-07 of December 11, 2009 [Electronic resource]. http://www.rosminzdrav.ru/docs/mzsr/letters/161
- Order of the Ministry of Health and Social Development of the RF of April 28, 2007 No. 307. On the Standard of Dispensary (Routine) Observation over a Child during the First Year of Life. http://www.garant.ru/products/ipo/prime/doc/4084665/
- Note for guidance on harmonization of requirements for influenza vaccines (CPMP/BWP/214/96). http://www.ema.europa.eu/docs/en_GB/document_library/
The fully formatted PDF version is available.
Int J Biomed. 2015; 5(4):179-183. © 2015 International Medical Research and Development Corporation. All rights reserved.