Far Eastern Scientific Center of Physiology and Pathology of Respiration,Siberian Branch of Russian Academy of Medical Sciences; Blagoveshchensk, Russian Federation
*Corresponding author: Prof. Michael T. Lucenko, PhD, ScD, Academician of RAMS, Head of Far Eastern Scientific Center of Physiology and Pathology of Respiration SB of RAMS, Blagoveshchensk, the Russian Federation E-mail: Lucencomt@mail.ru
Published: December 3, 2015. DOI: 10.21103/Article5(4)_OA2
The aim of this study was to estimate the changes in humoral immunity and their association with complications of pregnancy (spontaneous abortions, threatened miscarriage, premature birth) depending on the gestational age and recurrence of cytomegalovirus infection (CMVI). A direct relationship between the frequency of detection of an anti-CMV IgG antibody titer of 1:1600 and the prevalence of acute respiratory disease during pregnancy has been identified. We found an imbalance in the production of the non-specific antibodies (an increase in the blood levels of total IgM and a decrease in IgA and IgG levels) in the subgroup of women with relapsed CMVI at 6 to 8 weeks of gestation and spontaneous abortion, as well as in the subgroup of women with relapsed CMVI at 15 to 21 weeks of gestation and the risk of the late miscarriage, compared to those with relapsed CMVI at 9 to 14 weeks and 22 to 32 weeks of gestation. An increase in blood levels of total IgM and IgG and a decrease in IgA level was identified in the subgroup of women with relapsed CMVI at 9 to14 weeks of gestation and a threatened abortion, as well as in the subgroup of women with relapsed CMVI at 22 to 32 weeks of gestation and preterm birth. The obtained data of the imbalance in the primary and secondary immune response in CMV- seropositive pregnant women during relapsed CMVI indicate disturbances in the systemic and local intercellular interactions of immunocompetent cells, which lead to an imbalance in the production of antibodies involved in the elimination of viral agents and to the development of a systemic inflammatory response that complicates the course of pregnancy. CMVI relapse at 7 to 8 weeks of gestation is associated with reproductive losses; a risk for threatened miscarriage, threatened premature labor, and retrochorial hematoma increases significantly with CMVI relapse in the more remote gestational age.
- Kulakov VI, Gurtovoiy BL, Ordzhonikidze NV. Cytomegalovirus infection in obstetrics. M.: GEOTAR-Media, 2001. [in Russian].
- Orekhov KV, MV Golubeva, Barycheva LY. Congenital cytomegalovirus infection. Detskie Infektsii 2004; 1:49-55. [in Russian].
- Alekseeva ML, Ekimov AN, Ekimova VE, Ivanec Yu, Kolod’ko VG. The approaches to the diagnosis of cytomegalovirus infection in obstetrics and neonatology. Problemy Reproduktsii. 2010; 5: 52-56. [in Russian].
- Vladimirova NYu, Nikitin VG, Chizhova GV. Planning for pregnancy in women with asymptomatic CMV infection. Dal’ne-Vostochniy Zhurnal Infect Pathol. 2012; 21:71-73. [in Russian].
- Grigorieva EA, Moscow IA, Atyasheva LN, Nikiforova NN. Perinatal cytomegalovirus infection (clinical and laboratory parallels). Epidemiologia Infect Boleznei. 2003;1:40-42. [in Russian].
- Ozhegov AM, Maltsev SV, Myakishev LS. Clinical and immunological characteristics of active CMV infection with co-infection in children of the first year of life. Pediatriia. 2001; 2:26-31. [in Russian].
- Asrankulova D, Rizopulu AP, Kurbanov DD. The immune status and anti-inflammatory cytokines in pregnant women with acute cytomegalovirus infection. Zh Microbiol Epidemiol Immunol 2004;4:84-86. [in Russian].
- Revello MG, Gerna G. Diagnosis and management of human cytomegalovirus infection in the mother, fetus and newborn infant. Clin Microbiol Rev. 2002; 15(4): 680-715.
- Dolgikh TI, Dalmatov VV, Gashina EA, Stasenko VL, Kosykh NI, Kmito NL, Pakhalkova EV. Epidemiological aspects of cytomegalovirus infection in babies aged under one. Zh Mikrobiol Epidemiol Immunobiol. 2004;(5):25-30. [in Russian].
- Kisteneva LB. Cytomegalovirus infection as a problem of perinatal pathology: classification, clinical presentation, differential diagnosis, treatment, and prevention. Ross Vest Perinatol Pediatrii. 2003; 5:52-56. [in Russian].
- Sidelnikova VM, Dadalyan DG, Van’ko LV, Sukhih GT. Cytomegalovirus infection in women with recurrent miscarriage. Akush Ginekol (Mosk). 1996;4:21-24. [in Russian].
- Klimov VA. Infectious diseases and pregnancy. M .: MEDpress; 2009. [in Russian].
- Andrievskaya IA. Morphofunctional characteristics of the placenta and disorders in metabolism of hormones and bioactive substances in pregnant women with herpes virus infection. Abstract of PhD thesis. Irkutsk , 2004. [in Russian].
- Lucenko MT, Solovieva AS, Andrievskaya IA. Mechanisms of changes in immune system of pregnant women with herpes viral infection. Novosibirsk- Blagoveshchensk: Publishing House of ASMA; 2007. [in Russian].
- Moskalev AV, Sboychakov VB. Infectious Immunology. In: Lobzina YuV, editor. SPb.: Foliant; 2006. [in Russian].
- Konstantinova NA. Immune complexes and tissue damage. M.: Medicine; 1996. [in Russian].
- Gabelova KA, Arutyunyan AV, Zubzhitskaya LI, et al. Fixed immune complexes and NO-synthase activity in the placenta during preeclampsia. Vestnik Ross Assotsiatsii Akush Ginekol. 2000; 1:22-24. [in Russian].
- Starostina TA, Belokrinitskiĭ DV, Kudriashova NM, Razmakhnina NI, Goloshchapova OV, Seredina TA. Circulating immune complexes and immunoglobulins A, M and G in the mother-fetus system in normal pregnancy and gestosis. Akush Ginekol (Mosk). 1992; 1: 19-22. [in Russian].
- Babenko OP. Morphofunctional characteristics of the placenta during exacerbation of cytomegalovirus infection in the early stages of gestation. Bull Physiol Pathol Resp (SB RAMS) 2013; 47:72-76. [in Russian].
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Int J Biomed. 2015; 5(4):184-187. © 2015 International Medical Research and Development Corporation. All rights reserved.