New Features of Molecular Diagnostics of Ulcerative Colitis

ORIGINAL ARTICLE
A.S. Volkov, PhD¹; I.G. Stolyarova, PhD¹; I.V. Sarvilina, PhD, ScD³*

1Rostov-on-Don State Medical University, Rostov-on-Don, Russian Federation; 2Medical Centre "Novomeditsina", Rostov-on-Don, Russian Federation

*Corresponding author: Irina V. Sarvilina, PhD, ScD. CEO of Medical Centre «Novomeditsina», Rostov-on-Don, Russian Federation. E-mail: isarvilina@mail.ru

Published: March 16, 2016. DOI: 10.21103/Article6(1)_OA15

Abstract: 

The purpose of this study was to search for new molecular markers for the diagnosis of ulcerative colitis (UC).

The study included 65 patients (range from 22 to 35 years, 24 men and 41 women) with left-sided UC (Montréal classification), mild and moderate activity, infrequent (≤1/year) relapses according to the inclusion/exclusion criteria in the research. Criteria of the diagnosis of UC corresponded to ECCO Consensus [11]. The duration of UC was 5.3 years. The control group included 30 healthy individuals. Molecular phenotyping of colon mucosa was processed with methods of proteomics. The data of the molecular interactions were received with STRING 10.0 database. Potentially new molecular markers of the development of UC were identified

Keywords: 
ulcerative colitis; colon mucosa; proteomics; diagnostic markers.
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Int J Biomed. 2016; 6(1):70-73. © 2016 International Medical Research and Development Corporation. All rights reserved.