Association of Chronic HBV Infection with Chronic Lymphoproliferative Disorders: A Review and Case Report

Snezhana S. Sleptsova, PhD, ScD¹; Vera N. Yadrichinskaya, PhD¹; Aida M. Palchina, PhD¹; Nataliya V. Borisova, PhD, ScD¹; Inna M. Mulina²; Svetlana N. Parfenova²; Lev S. Butaev¹; Lyubov D. Indeeva, PhD³

¹North-Eastern Federal University named after M.K. Ammosov, Yakutsk; ²Republican Hospital №1, National Center of Medicine, Yakutsk; ³Yakutsk city clinical hospital; the Republic of Sakha (Yakutia), Russia

Corresponding author:  Nataliya V. Borisova, PhD, ScD. North-Eastern Federal University named after M.K. Ammosov, Yakutsk, the Republic of Sakha (Yakutia), Russia  E-mail: borinat@yandex.ru

Published: June 20, 2016.  DOI: 10.21103/Article6(2)_CRep1

Abstract: 

This article presents a clinical report on the associated course of chronic hepatitis B virus (HBV) infection with Castleman's disease (CD). We noticed the reactivation of previously latent chronic hepatitis B (CHB) with high replicative activity of HBV DNA during the treatment of lymphoproliferative disease. This clinical case dictates the need for pre-emptive therapy of HBV infection with nucleoside analogues in patients who are receiving chemotherapy.

Keywords: 
chronic hepatitis B; Castleman's disease; chemotherapy; rituximab; reactivation of viral infextion.
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