Reproductive Function in Patients with Non-functioning Pituitary Adenoma According to the Register of the Republic of Uzbekistan

Zamira Yu. Halimova, PhD, ScD¹; Dilorom Sh. Kholova¹; Yulduz Urmanova, PhD, ScD¹,²; Dinara A. Alieva, PhD¹; Gul’ruh A. Alimukhamedova, PhD¹; Khurshida K. Nasirova, PhD¹

¹Republican Specialized Scientific-Practical Medical Center of Endocrinology; ²Tashkent Medical Pediatric Institute; Tashkent, Uzbekistan

Corresponding author: Yulduz Urmanova, PhD, ScD.  Republican Specialized Scientific-Practical Medical Center of Endocrinology;  Tashkent, Uzbekistan. E-mail:

Published: June 20, 2016.  DOI: 10.21103/Article6(2)_ShC1


The main aim of our study was to evaluate the reproductive system status and gonadotropic pituitary function in patients with non-functioning pituitary adenoma (NFPA) according to the register data.

Depending on the state of the reproductive system at the time of NFPA diagnosis, men and women can be classified into three groups: secondary hypogonadism (40.7%); normal state of the sexual system (22.0%); and PCOS in women (36.5%) and reduced testicular size in men (11.2%). Menstrual irregularities took place in 77.8% NFPA women of reproductive age (41.3% of them had galactorea-oligo/amenorrhea combined with moderate hyperprolactinemia), and sexual dysfunction occurred in 42.0% of male patients with NFPA.

non-functioning pituitary adenoma; hypopituitarism; reproductive function; gonadotropins.
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Int J Biomed. 2016;6(2):133-135. © 2016 International Medical Research and Development Corporation. All rights reserved.