The Research Progress of SiRNA Targeting Notch1 on Tumor Cells: A Mini Review of the State of the Art

Lanfen Huo¹, Shaoling Wu¹*, Zhonghai Chi², Xindong Zhao³

¹Department of Hematology, Affiliated Hospital, Qingdao University, Shandong, P.R. China; ²Hospitals of Traditional Chinese and Western Medicine, Cangzhou city, Hebei, P.R. China;  ³Department of Hematology, Medical College of Qingdao University, Qingdao, Shandong, P.R. China

*Corresponding authors: Prof. Shaoling Wu, Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, , P.R. China; E-mail:

Published: September 12, 2016.  DOI: 10.21103/Article6(3)_RA1


Notch signaling is a highly conserved signaling pathway, playing an important role in a variety of cell differentiation, development and regulation. Notch signaling includes Notch1-4; Notch1 gene encodes Notch1 signaling that can shorten cell cycle, enhance cell proliferation, inhibit cell differentiation, and promote apoptosis. Mutation and overexpression of the Notch1 gene may induce tumorigenesis, which plays an important role in the development of tumors across a variety of signaling pathways. Currently, using RNA interference technology (RNAi) synthesizing small interference RNA (siRNA) targeting Notch1 gene(siNotch1)has become a hot topic, and clinical application of gene silencing has also obtained a certain therapeutic effect. In this paper, the application of Notch1 gene silencing in tumor progress was reviewed.

RNAi; Notch signaling; Notch1 gene; tumor cells.
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