Republican Center of Cardiology, Tashkent, Uzbekistan
*Corresponding author: Nigora Z. Srojidinova, PhD. The Republican Specialized Center of Cardiology, Tashkent, Uzbekistan. E-mail: firstname.lastname@example.org
Published: September 12, 2016. DOI: 10.21103/Article6(3)_OA2
The objective of this study was to evaluate the frequency of inappropriate left ventricular (LV) mass (iLVM) and factors associated with iLVM in hypertensive patients with metabolic syndrome (MetS). The study included 178 male patients (mean age 45.9±10.5 yrs) with hypertension (HT) and MetS. iLVM in HT patients with MetS was associated with LV diastolic dysfunction and an intensity of vascular remodeling process. Hyperinsulinemia contributes to LVM appropriateness, which aggravates the cardiovascular remodeling with development of the significant LV diastolic dysfunction and endothelium dysfunction.
- Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561-6.
- de Simone G, Verdecchia P, Pede S, Gorini M, Maggioni AP. Prognosis of inappropriate left ventricular mass in hypertension. Hypertension. 2002;40:470-6.
- Palmieri V, de Simone G, Roman MJ, Schwartz JE, Pickering TG, Devereux RB. Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass. Hypertension. 1999;34:1032-40.
- de Simone G, Pasanisi F, Contaldo F. Link of nonhemodynamic factors to hemodynamic determinants of left ventricular hypertrophy. Hypertension. 2001;38:13-8.
- Celentano A, Palmieri V, Esposito ND, et al. Inappropriate left ventricular mass in normotensive and hypertensive patients. Am J Cardiol. 2001;87:361-3, A10.
- de Simone G, Kitzman DW, Palmieri V, et al. Association of inappropriate left ventricular mass with systolic and diastolic dysfunction.Am J Hypertens. 2004;17:828-33..
- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28:412– 419.
- Alberti KG, Zimmet P, Shaw J. The metabolic syndrome–a new worldwide definition. Lancet. 2005; 366:1059-1062.
- Mancia G, de Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 Guidelines for the Management of Arterial Hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007; 25:1105–1187.
- Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol. 1976; 37:7–11.
- de Simone G, Devereux RB, Kimball TR, Mureddu GF, Roman MJ, Contaldo F, Daniels SR. Interaction between body size and cardiac workload: influence on left ventricular mass during body growth and adulthood. Hypertension. 1998;31:1077–1082.
- de Simone G, Devereux RB, Roman MJ, Ganau A, Saba PS, Alderman MH, Laragh JH. Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension [published erratum appears in J Am Coll Cardiol. 1994;24:844]. J Am Coll Cardiol. 1994;23:1444–1451.
- de Simone G., Verdecchia P., Pede S., Gorini M., Maggioni A.P. Prognosis of Inappropriate Left Ventricular Mass in Hypertension. The MAVI Study. Hypertension. 2002;40:470-476.
- de Simone G, Palmieri V, Koren M, Mensah G, Roman MJ, Devereux RB. Prognostic implications of the compensatory nature of left ventricular mass in arterial hypertension. J Hypertens. 2001;19:119 –125.
The fully formatted PDF version is available.
Int J Biomed. 2016;6(3):170-173. © 2016 International Medical Research and Development Corporation. All rights reserved.