Dynamic Networks of Human Homeostatic Control in Norm (Part 2)

ORIGINAL ARTICLE
Alexander G. Kruglov, PhD, ScD*; Georgiy Ya. Gebel†, PhD, ScD; Valery N. Utkin; Alexander Yu. Vasiliev, PhD, ScD; Veronica A. Sherman

Central Research Institute of Radiation Diagnosis; Moscow, the  Russian Federation.

*Corresponding author:  Alexander G. Kruglov, PhD, ScD. Moscow State University of Medicine and Dentistry, Moscow, Russian Federation. E-mail: krag48@mail.ru

Published: September 12, 2016.  DOI: 10.21103/Article6(3)_OA4

Abstract: 

We undertook this research to study the relationships between elements of the vascular system in individuals without clinical signs of pathology (in "norm"). Indicators of hemodynamics obtained by catheterization in various vascular areas (RA, RV, LV, PT, Ao, SS, RHV (FHVP and HVWP), CS) were the pressure levels (mmHg). During the correlation analysis, the significant (p<0.05) relation signs (+, 0, -) without regard to their power were considered.

The obtained results allow us to draw following conclusions:

  • Capacitive venous vessels of the liver are a communication channel between the evolutionarily younger (lungs) and older (SP organs) functional systems of the human body.
  • Hepatic venous circulation is a field of interference of the information and biochemical relationships between the body and the external environment through the venous outflow from GIT (the zone preceding the liver) and arterial flow - CHA (an indicator of aortic hemodynamics and gas exchange in lungs).
  • The result of marked interactions is an integrated BIF of venous outflow from the liver (whose “thesaurus” includes the information volumes of organs preceding the liver), which has uniform hemodynamic and biochemical parameters and interacts with the blood flow of RA and all phases of CC and hemodynamics in IVC/SVC pools and CS.
  • The intersystem relationship in the cardio-hepato-pulmonary complex of the human body is the highest biology hierarchical level of the homeostatic relationships in the human–external-environment system.
Keywords: 
human homeostasis control matrix; hydrodynamic balance; hepatic venous outflow; coronary sinus
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