Association Between IL1B and SCN1A Polymorphism and Febrile Seizures in Children in Siberia

Maria A. Stroganova, MD¹; Diana V. Dmitrenko, PhD, ScD¹; Ivan P. Artyukhov, PhD, ScD¹; Svetlana N. Zobova, PhD¹,²; Galina P. Martynova, PhD, ScD¹; Natalia A. Shnayder, PhD, ScD*¹; Anna V. Dyuzhakova, MD¹

¹V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, ²Scientific Research Institute of Medical Problems of the North. Krasnoyarsk, The Russian Federation

 *Corresponding author:  Prof. Natalia A. Shnayder, PhD, ScD.  V.F. Voino-Yasenetsky Krasnoyarsk State Medical University.  Krasnoyarsk, the Russian Federation.  E-mail:

Published: June 16, 2017.  doi: 10.21103/Article7(2)_OA2


Background: Febrile seizures (FS) are a benign, age-dependent, genetically determined state, in which the child’s brain is susceptible to epileptic seizures occurring in response to hyperthermia. We assessed whether polymorphisms of IL1B and SCN1A genes, encoding the proinflammatory cytokine IL1B and SCN1A, respectively, could help to predict FS development and find a new way to treat FS.
Methods: We examined 121 children with FS and 30 children with HTS aged from 3 to 36 months. SNPs rs1143634 and rs16944 of IL1B gene, and rs3812718 and rs16851603 of SCN1A gene were determined by quantitative real-time PCR.
Results: The analysis for rs1143634 revealed an association between the CC genotype and increased risk of FS development (OR 6.56; P=0.0008) against the background of acute respiratory viral infection. The same result was obtained for rs16944 (OR 3.13; P=0.04) and an association of two homozygous genotypes CC/CC. For rs3812718, the carriage of heterozygous genotype CT demonstrated a direct relationship with FS development (OR 44.95; P=0.000).
Conclusion: Children with high FS risk need preventive treatment and joint observation of a pediatrician, pediatric infectionist, and a neurologist-epileptologist. 

febrile seizures ● IL1B gene ● SCN1A gene ● single nucleotide polymorphisms.

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International Journal of Biomedicine. 2017;7(2):96-103. © 2017 International Medical Research and Development Corporation. All rights reserved.