Efficacy of Oxidative Stress Correction During Asthma Treatment

Andrey V. Budnevsky, PhD, ScD; Vyacheslav M. Provotorov, PhD, ScD; Evgeniy S. Ovsyannikov, PhD*; Yuliya I. Filatova

Voronezh State Medical University named after N. N. Burdenko, Voronezh, The Russian Federation

*Corresponding author: Evgeniy S. Ovsyannikov, PhD. Department of faculty therapy, Voronezh State Medical University named after N.N. Burdenko. Voronezh, Russia.  E-mail: ovses@yandex.ru.

Published: June 16, 2017.  doi: 10.21103/Article7(2)_OA3


Background: The improvement of asthma treatment is still one of the urgent issues of modern medicine. The objective of this study was to evaluate the dynamics of lipid peroxidation parameters in patients with asthma receiving complex therapy with ceruloplasmin (Cp).
Methods and Results: The study included 92 patients with severe uncontrolled asthma. Patients were divided into 2 groups. The case group consisted of 45 patients, whose treatment was conventional therapy combined with Cp produced by “MICROGEN” (Russia). Cp 100 mg was administered intravenously once daily for 7 days. The control group consisted of 47 patients who received conventional treatment: inhaled and systemic corticosteroids, bronchodilators, and, if necessary, antibiotics and oxygen therapy. All participants underwent a comprehensive examination, including clinical investigation, chest radiography, assessment of spirometry parameters (VC, FVC, FEV1, FEV1/FVC ratio, PEFR, FEF 25-75), and determination of MDA, metHB, HbCO, total sulfhydryl groups, and SOD activity in blood plasma. Patients of the case group showed a statistically significant decrease in elevated rates of MDA and HbCO, an increase in SOD activity and the content of sulfhydryl groups.
Conclusion: Cp in complex treatment of patients with asthma allows eliminating the imbalance in the prooxidant-antioxidant system and providing an obviously positive clinical effect. 

asthma ● lipid peroxidation ● oxidative stress ● ceruloplasmin

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International Journal of Biomedicine. 2017;7(2):104-107. © 2017 International Medical Research and Development Corporation. All rights reserved.