Associations of Polymorphic Variants of the Biotransformation Genes with the Components of the Glutathione System in Men with Infertility

N.A. Kurashova, PhD*¹; M.I. Dolgikh, PhD¹; O.A. Ershova, PhD¹; O.A. Gavrilova¹; E.V. Osipova, PhD, ScD¹; B.G. Dashiev²; T.A. Bairova, PhD, ScD¹; S.I. Kolesnikov, PhD, ScD¹,³; L.I. Kolesnikovа, PhD, ScD¹

¹Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk; ²Republican Perinatal Center, Ulan-Ude; ³Lomonosov Moscow State University, Moscow; the Russian Federation

*Corresponding author: Nadezhda A. Kurashova, PhD. Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian Federation. E-mail:

Published: September 16, 2017.  doi: 10.21103/Article7(3)_OA13


The aim of this research was to investigate the glutathione system components and their association with polymorphisms GST genes in men with infertility.
Materials and Methods: One hundred and sixty Russian men of reproductive age (Caucasians) who came to the public health institution Republican Perinatal Center in Ulan-Ude with an infertility problem of one year and more after marriage were included in the main group. The control group included 104 men with proven fertility. DNA samples were genotyped for polymorphisms in GSTP1, GSTT1 and GSTM1genes and activity of glutathione system enzymes was determined.
Results: The most informative genetic and metabolic indicators in Caucasian males with infertility were combinations of the null genotypes GSTT1(*0/*0)+GSTM1(*0/*0) associated with a decrease  of GST activity in blood and ejaculate and an increase of GSH and GPO in the blood. Another combination is GSTP1(Ile105Val)+GSTP1(Ala114Val), which is associated with suppression of the blood and ejaculate GPO activity and a decrease in blood concentration of GSH.  

male ● infertility● GSTP1● GSTM1● GSTT1● glutathione

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International Journal of Biomedicine. 2017;7(3):226-230. ©2017 International Medical Research and Development Corporation. All rights reserved.