HIV-associated Tuberculosis: Clinical Case
¹M. K. Ammosov North-Eastern Federal University, Yakutsk; ²PKZ SPID I IZ, Perm; ³Yakut NPZ “Ftiziatriia”, Yakutsk; the Russian Federation
*Corresponding author: Snegana S. Sleptsova, PhD, ScD. M. K. Ammosov North-Eastern Federal University. Yakutsk, the Sakha Republic, Russia. E-mail: email@example.com
Published: September 16, 2017. doi: 10.21103/Article7(3)_CR2
This case report presents a 35-year-old female who presented with HIV-associated multidrug-resistant tuberculosis. Resistant tuberculosis in HIV-infected patients with immunodeficiency is extremely difficult for effective treatment. Nevertheless, our clinical case showed that the cure of tuberculosis is possible in the late stages of HIV infection with the correct choice of treatment tactics, taking into account the resistance of MBT with the subsequent use of antiretroviral therapy. The progression of HIV infection, against the background of the effective antituberculous therapy, was associated with the patient's refusal to treat the underlying disease.
1. The Global HIV/AIDS Epidemic. Available from: https://www.hiv.gov/hiv-basics/overview/data-and-trends/global-statistics
2. Global Health Observatory (GHO) data. HIV/AIDS. Available from: http://www.who.int/gho/hiv/en/
3. Vasilyeva IA, Pokrovsky VV, Aksenova VAB Mariandyshev AO, Ergeshov AE, Chernousova LN, Zimina VN, et al. Federal clinical guidelines for the diagnosis and treatment of tuberculosis in patients with HIV infection. M.-Tver: "Triada"; 2014. [in Russian].
4. Global Tuberculosis report 2015 WHO. Available from: http://www.who.int/tb/publications/global_report/gtbr15_main_text.pdf
5. TB/HIV facts 2015 Available from: http://www.who.int/hiv/topics/tb/tbhiv_facts_2015/en/
6. Kornilova ZKh, Lukonina IV, Alekseeva LP. [Tuberculosis concurrent with HIV infection]. Tuberk Biolezni Legkih. 2010;(3):3-9. [Article in Russian].
7. Eramova I, Matic S, Mun M. Tuberculosis and HIV infection: management tactics of patients with co-infection. Clinical protocol for the WHO European Region. 2006: 8-23.
8. Moore D, Liechty C, Ekwaru P, Were W, Mwima G, Solberg P, et al. Prevalence, incidence and mortality associated with tuberculosis in HIV-infected patients initiating antiretroviral therapy in rural Uganda. AIDS. 2007;21(6):713-9.
9. Van Rie A, Westreich D, Sanne I. Tuberculosis in patients receiving antiretroviral treatment: incidence, risk factors, and prevention strategies. J Acquir Immune Defic Syndr. 2011;56(4):349-55. doi: 10.1097/QAI.0b013e3181f9fb39.
10. Gupta A, Wood R, Kaplan R, Bekker LG, Lawn SD. Tuberculosis incidence rates during 8 years of follow-up of an antiretroviral treatment cohort in South Africa: comparison with rates in the community. PLoS One. 2012;7(3):e34156. doi: 10.1371/journal.pone.0034156.
11. Badri M1, Ehrlich R, Wood R, Pulerwitz T, Maartens G. Association between tuberculosis and HIV disease progression in a high tuberculosis prevalence area. Int J Tuberc Lung Dis. 2001;5(3):225-32
12. López-Gatell H, Cole SR, Hessol NA, French AL, Greenblatt RM, Landesman S, et al. Effect of tuberculosis on the survival of women infected with human immunodeficiency virus. Am J Epidemiol. 2007;165(10):1134-42.
13. Vanham G, Edmonds K, Qing L, Hom D, Toossi Z, Jones B, et al. Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection. Clin Exp Immunol. 1996;103(1):30-4.
14. Wolday D, Tegbaru B, Kassu A, Messele T, Coutinho R, van Baarle D, Miedema F. Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patients. J Acquir Immune Defic Syndr. 2005;39(3):265-71.
15. Bondarenko VN. National clinical guidelines for the diagnosis and treatment of HIV infection in adults. M.; 2014.[in Russian].
The fully formatted PDF version is available.
International Journal of Biomedicine. 2017;7(3):257-259. ©2017 International Medical Research and Development Corporation. All rights reserved.