Central Research Institute of Radiation Diagnosis, Moscow, the Russian Federation
*Corresponding author: Alexander G. Kruglov, PhD, ScD. Central Research Institute of Radiation Diagnosis, Moscow, the Russian Federation. E-mail: krag48@mail.ru
Published: September 16, 2017. doi: 10.21103/Article7(3)_OA5
In practically healthy people on the background of self-breathing, we used catheterization to obtain blood samples from Ao, PT, SC, VJI, SS, VH and VR. We believe that the standard tests of blood gases by volume (pO2 and pCO2) and their A-V gradients, quantitatively determined, are insufficient to fully assess the hypoxic states both in the whole organism and in individual organs. To estimate gas homeokinesis, we performed integral gas tests, including an additive criterion of blood gases—pressure in mmHg: 1) the summary pressure of the plasma gases, PS; 2) Gas functional, the gradient between the total indices of arterial and vein gases (Gradient D); and 3) the exchange gradient, Gradient DP [(arterial pO2 – venous (pO2+pCO2)]. Each test indicator at all studied points was determined in mmHg. Correlation analyses were carried out between the parameters of all tests.
We found that the processes forming PS limit the amplitude of the PS deviation under changing parameters of the constituent components (pO2 and pCO2) due to acts of mutual replacement between them, as well as the influence of integral gas complexes under shifts in pO2, pCO2, A-V SO2. Unlike the generally accepted tests that record quantitative differences between the points studied, the integral gas tests allow us to identify vectors and mechanisms of adaptive changes in gas homeostasis, to perform a qualitative comparison of the functioning of the studied organs by gas-dynamic tests in the norm and in pathology.
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