Stability of Hyaluronan-Pectic Gel Particles in the Conditions of the Artificial Gastrointestinal Environment

Elena A. Mikhailova¹, Anatoly K. Melekhin¹, Vladimir A. Belyy, PhD²; Anatoly A. Shubakov, PhD¹

¹Institute of Physiology, Komi Science Centre, Ural Branch of the RAS; ²Institute of Chemistry, Komi Science Centre, Ural Branch of the RAS. Syktyvkar, Komi Republic, the Russian Federation

*Corresponding author: Elena A. Mikhailova. Department of Molecular Immunology and Biotechnology, Institute of Physiology, Komi Science Centre, Ural Branch of the RAS. Syktyvkar, the Russian Federation. E-mail:

Published: December 15, 2017.  doi: 10.21103/Article7(4)_OA8


Spherical hyaluronan-pectic gel particles (HPGPs) from hyaluronic acid (HA) and low-methyl esterified pectins of callus cultures (CC) of tansy, duckweed, campion and commercial apple pectin were obtained by the method of ionotropic gelation in the presence of calcium ions. We investigated the morphology, swelling and degradation of the obtained HPGPs in the conditions of a simulated gastrointestinal environment and established that the greatest stability in the artificial environment of the digestive tract is achieved with HPGPs obtained from the pectin of tansy CC. HPGPs can be used as potential carriers for drug delivery systems in parts of the small and large intestine.

hyaluronic acid ● pectin ● callus culture ● gel particles ● gastrointestinal environment
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International Journal of Biomedicine. 2017;7(4):310-314. ©2017 International Medical Research and Development Corporation. All rights reserved.