Relationship Between Indices of Oxidative Stress, Endothelial Dysfunction and Chaperone Activity and the Severity of Coronary Atherosclerosis

Julia A. Kotova, Anna A. Zuikova, Aleksander N Pashkov, Natalia V. Strahova, Olga N. Krasnorutskaya

International Journal of Biomedicine. 2018;8(3):182-185.   
DOI: 10.21103/Article8(3)_OA2
Originally published September 15, 2018  


The aim of this research was to study the relationship between the indices of oxidative stress, endothelial dysfunction and chaperone activity of proteins with the severity of coronary atherosclerosis. In patients with coronary heart disease, we found gender-related differences in the severity of coronary atherosclerosis. Significant differences in the indices of oxidative stress, endothelial dysfunction and chaperone activity were revealed depending on the severity of coronary atherosclerosis and the type of atherosclerotic lesion. The determination of studied parameters can serve as a good indicator of the severity of coronary atherosclerosis.

coronary heart disease • endothelial dysfunction • oxidative modification of proteins • superoxide dismutase
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Received May 7, 2018.
Accepted May 17, 2018.
©2018 International Medical Research and Development Corporation.