Characteristics of Lipid Peroxidation Processes and Antioxidant Status in Teenagers-Boys of Different Ethnic Groups with Exogenous Constitutional Obesity and Non-Alcoholic Fatty Liver Disease
International Journal of Biomedicine. 2018;8(4):306-310.
Originally published December 15, 2018
The aim of this research was to study changes in the LPO-AOD processes in Mongoloid and Caucasian teenagers with exogenous constitutional obesity (ECO), including those complicated by non-alcoholic fatty liver disease (NAFLD).
Materials and Methods: A total of 18 Mongoloid teenage boys and 17 Caucasian teenage boys with NAFLD (Clinical group 1 and Clinical group 2, respectively) on the background of ECO of the first degree were examined. For comparison, data of 37 apparently healthy Mongoloid teenage boys (Control group 1) and 23 Caucasian teenage boys (Control group 2) was used. The plasma level of antioxidant parameters (total antioxidant activity [TTA], SOD activity, α-tocopherol and retinol) and primary/secondary products of LPO (conjugated dienes [CD], ketodienes and conjugated trienes [KD-CT], and thiobarbituric acid reactive substances [TBARS]) were determined using spectrophotometric and fluorometric methods.
Results: Evaluation of the activity of LPO reactions in Clinical group 1 indicated an increase in the content of compounds with DB relative to Control group 1. A similar trend was found in the concentration of CD and KD-CT. In Clinical group 2, we found a statistically significant increase only in the values of KD-CT. In the parameters of the AOD system, multidirectional changes of patients parameters compared with the control group were observed in Clinical group 1: the increased values of TAA, SOD activity, and reduced levels of α-tocopherol, retinol, and GSSG. In Clinical group 2, lower values of α-tocopherol, GSSG, and SOD activity were observed relative to Control group 2. Differences between the two ethnic groups were present in the control groups—the reduced level of TAA, GSH and the increased level of GSSG in the group of Mongoloids; just as in clinical groups with NAFLD, a high level of SOD activity was observed in Mongoloids compared to Caucasians.
Conclusion: The changes revealed in the redox state in Mongoloid and Caucasian teenagers with ECO and NAFLD indicate high activity of LPO processes and severe deficiency of antioxidant vitamins in patients of both ethnic groups. The obtained results allow us to recommend administration of antioxidant drugs in addition to courses of metabolic therapy in comprehensive treatment of patients with ECO and NAFLD.
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Received November 2, 2018.
Accepted December 2, 2018.
©2018 International Medical Research and Development Corporation.