Predictors of Coronary Atherosclerosis: HSP70, Markers of Oxidative Stress and Endothelial Dysfunction

Julia A. Kotova, Anna A. Zuikova, Aleksander N Pashkov, Natalia V. Strahova, Olga N. Krasnorutskaya

International Journal of Biomedicine. 2019;9(2):97-101.
DOI: 10.21103/Article9(2)_OA2
Originally published June 15, 2019  


The aim of this study was to evaluate the role of HSP70, and markers of oxidative stress and endothelial dysfunction, as determinants of the severity of coronary atherosclerosis. The study revealed significant differences between groups with and without coronary atherosclerosis in terms of HSP70, superoxide dismutase (SOD), total homocysteine (tHcy) and markers of oxidative modification of proteins. Significant correlations between Gensini score, lipid profile parameters and studied markers were determined. The results of MLRA allow us to consider the levels of HSP70, tHcy, LDL-C and ketone derivative of 2.4-dinitrophenylhydrazine as factors associated with the risk of coronary atherosclerosis.

coronary atherosclerosis • heat shock protein 70 • superoxide dismutase • oxidative modification of proteins • homocysteine
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Received May 14, 2019.
Accepted June 12, 2019.
©2019 International Medical Research and Development Corporation.