Evaluation of the Effectiveness of Immunomodulatory Therapy in Chronic Obstructive Pulmonary Disease

ORIGINAL ARTICLE
Anna A. Zuikova, Olga N. Krasnorutskaya, Julia A. Kotova, Daniil Yu. Bugrimov, Natalia V. Strahova, Elena Yu. Esina, Olga V. Kashaeva, Olga A. Paevskaya

 
International Journal of Biomedicine. 2019;9(4):300-303.
DOI: 10.21103/Article9(4)_OA5
Originally published December 15, 2019

Abstract: 

The purpose of our study was to evaluate the effectiveness of sodium deoxyribonucleate (Derinat, solution for intramuscular injection) in combination with standard therapy in the treatment of COPD Group C patients in outpatient settings.
Materials and Methods: The study included 80 patients (43 men and 37 women) with COPD (Group C), mean age of 51.7±1.4 years. Blood sampling for the study was carried out 3 times—before the start of therapy, and on days 5 and 15. Using monoclonal antibodies, we determined the number of lyphocytes carrying markers CD3+, CD+, CD8+, and CD72+. The quality of life (QL) indicators were evaluated using the St. George’s Respiratory Questionnaire (SGRQ). For at least 15 days, patients received standard COPD therapy. All patients were divided into 2 groups: Group 1 included 41 patients who received Derinat 75 mg intramuscularly once daily for 5 days; then - 5 injections with an interval of 48 hours against the background of standard therapy. Group 2 included 39 patients who continued to receive standard COPD therapy.
Results: The inclusion of Derinat in the complex therapy of COPD contributed to the normalization of the T-cell to B-cell ratio, an increase in the number of T suppressors. Assessing the clinical effects of combination therapy with the inclusion of the studied drug, a marked decrease in shortness of breath, cough, and the amount of sputum excreted can be noted in comparison with standard therapy. The improvement of the immunological status and clinical indicators against the background of complex therapy was accompanied by an increase in QL.

Keywords: 
sodium deoxyribonucleate • pro-inflammatory mediators • immunomodulatory therapy
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Received August 23, 2019.
Accepted September 27, 2019.
©2019 International Medical Research and Development Corporation.