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Comparative study on preventative SMA therapies shows mixed outcomes

Rss Feed - Tue, 06/25/2024 - 22:29
In a first-of-its-kind study, researchers compared the efficacy of preventative therapy for spinal muscular atrophy (SMA) between two well-matched study groups, using either gene therapy (onasemnogene abeparvovec) alone or in combination with risdiplam (oral medication) or nusinersen (intrathecal injection) administered before apparent signs of disease emerged.

Breakthrough biomarker predicts recurrence risk in clear cell renal cancer

Rss Feed - Tue, 06/25/2024 - 22:18
Researchers from the University of Michigan Health Rogel Cancer Center have discovered a biomarker that could help identify which renal cancer patients have a higher risk of recurrence.

Prunes may protect bone structure and strength in postmenopausal women, study reveals

Rss Feed - Tue, 06/25/2024 - 21:18
Dairy isn't the only food that's good for bone health. Prunes may also protect bone structure and strength in postmenopausal women, according to a new study led by Penn State researchers.

Study reveals brain health benefits of intermittent fasting and healthy diet plans

Rss Feed - Tue, 06/25/2024 - 21:14
Researchers from Johns Hopkins Medicine and the National Institutes of Health's National Institute on Aging say their study of 40 older adults with obesity and insulin resistance who were randomly assigned to either an intermittent fasting diet or a standard healthy diet approved by the U.S. Department of Agriculture (USDA) offers important clues about the potential benefits of both eating plans on brain health.

Physical activity significantly reduces all-cause and cardiovascular mortality risks in older adults

Rss Feed - Tue, 06/25/2024 - 20:50
Physical activity significantly reduces all-cause and cardiovascular mortality risks in older adults, especially those with low socioeconomic status.

Human milk banks improve infant health but can't fully replace mother's milk

Rss Feed - Tue, 06/25/2024 - 20:18
Scientists investigate human milk banks and their impact on infant health, highlighting differences between donated and maternal milk in gut microbiota and development.

Using real-world data to assess medication-related liver toxicity

Rss Feed - Tue, 06/25/2024 - 14:57
The current method for assessing medication-related liver injury is not providing an accurate picture of some medications' toxicity-;or lack thereof-;to the liver, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Weill Cornell Medicine receives $1.5M grant to predict prostate cancer bone metastasis

Rss Feed - Tue, 06/25/2024 - 14:50
Weill Cornell Medicine received a $1.5 million grant from the U.S. Department of Defense Prostate Cancer Research Program to develop new approaches for predicting the spread of cancer cells to the bone in men with prostate cancer, using tumor samples taken at early stages of the disease.

MRI connectome predicts gray matter atrophy progression in early Parkinson's disease

Rss Feed - Tue, 06/25/2024 - 11:25
The structural and functional organization of the brain as shown on MRI can predict the progression of brain atrophy in patients with early-stage, mild Parkinson's disease, according to a study published today in Radiology, a journal of the Radiological Society of North America (RSNA).

Sleep patterns reveal hidden health clues

Rss Feed - Tue, 06/25/2024 - 10:58
Your sleep tracker might give you information about more than just your sleep–specifically, it might give you information about chronic conditions such as diabetes and sleep apnea, and illnesses such as COVID-19.

Genetic variation in people of African ancestry linked to increased risk of diabetes complications

Rss Feed - Tue, 06/25/2024 - 09:15
A genetic variation common in people of African ancestry is associated with an increased risk of complications from diabetes, including diabetic retinopathy, according to a report published June 25 in the journal Nature Medicine.

Nitrate from plant sources linked to lower risk of mortality

Rss Feed - Tue, 06/25/2024 - 09:03
New research from Edith Cowan University (ECU) has found that nitrate from plant sources is associated with a lower risk of mortality while nitrate from other sources such as animal-based foods, processed meat and tap water, is linked to a higher risk of mortality.

Wearable devices show how sleep patterns change with health conditions

Rss Feed - Tue, 06/25/2024 - 04:49
Examine changes in the sleep phenotype of an individual over time and to determine if these changes in sleep patterns or phenotypes are informative about periods of acute illness.

Research shows gut bacteria's role in mental resilience and reduced anxiety

Rss Feed - Tue, 06/25/2024 - 04:28
Researchers characterized brain-gut microbiome (BGM) patterns related to stress resilience.

New research challenges current practices for premature babies

Rss Feed - Tue, 06/25/2024 - 02:55
Giving very premature babies high concentrations of oxygen soon after birth may reduce the risk of death by 50 percent, compared to lower levels of oxygen says new research led by University of Sydney researchers.

Open-source platform enables high-definition spatial transcriptomics

Rss Feed - Tue, 06/25/2024 - 02:42
An open-source platform developed by researchers in Nikolaus Rajewsky's lab at the Max Delbrück Center creates molecular maps from patient tissue samples with subcellular precision, enabling detailed study and potentially enhancing routine clinical pathology. The study was published in "Cell."

MicroRNAs shed light on aggressive youthful type 2 diabetes

Rss Feed - Tue, 06/25/2024 - 02:28
Type 2 diabetes in young people ages 10 to19 has more than doubled in the past 20 years, yet it remains difficult for physicians to predict who will be diagnosed and who will improve with treatment. A newly published study from the University of Oklahoma shows that measuring the circulating abundance of microRNAs – which affect insulin-producing beta cells in the pancreas – is likely as effective as measuring the level of sugar in the blood for determining how a young person with the condition will fare.

Beyond genes, new research explores mechanics and calcium signaling

Rss Feed - Tue, 06/25/2024 - 02:11
Using animals to study heart disease doesn't always translate well to human health outcomes, and human heart cells available for research don't work outside the human body.

Multi-regional sampling uncovers hidden complexity in liver cancer

Rss Feed - Tue, 06/25/2024 - 01:53
A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) and funded by the National Research Foundation Singapore (NRF) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of HCC harbors more than one molecular subtype within the same tumor and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype.

RENEW system utilizes machine learning for rare disease diagnosis

Rss Feed - Tue, 06/25/2024 - 01:26
At Mayo Clinic, the mission to solve the unsolvable is at the heart of every rare disease case. Each diagnosis is a testament to perseverance, innovation and the relentless pursuit of answers.

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