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Updated: 34 min 29 sec ago

Control trial proves effectiveness of repurposed drugs for COVID-19 treatment

Fri, 10/16/2020 - 12:36
In just six months, the world's largest randomized control trial on COVID-19 therapeutics has generated conclusive evidence on the effectiveness of repurposed drugs for the treatment of COVID-19.

Gene variants may provide clues to successful treatment of pediatric eosinophilic esophagitis

Fri, 10/16/2020 - 12:24
A group of three gene variants, commonly inherited together, may provide clues to more successful treatment of pediatric eosinophilic esophagitis (EoE), a chronic inflammation of the food pipe often confused with gastroesophageal reflux disease (GERD).

Study explores low back pain and its impact on athletes’ experience

Fri, 10/16/2020 - 12:24
Trinity College Dublin researchers have carried out the first multi-centred, international, qualitative study exploring the athlete experience (in their own words) of sporting low back pain (LBP).

New article explores the endemic potential of COVID-19 virus

Fri, 10/16/2020 - 12:18
A new article by Columbia Mailman School researchers Jeffrey Shaman and Marta Galanti explores the potential for the COVID-19 virus to become endemic, a regular feature producing recurring outbreaks in humans.

Novel method can predict influenza epidemics

Fri, 10/16/2020 - 12:12
Researchers at Linköping University, Sweden, have developed a unique method to predict influenza epidemics by combining several sources of data.

CRISPR-based engineered cell lines can accelerate potential treatment targets for SARS-CoV-2

Fri, 10/16/2020 - 12:10
Synthego, the genome engineering company, has collaborated with The Krogan Lab, a world-renowned scientific research unit at the Quantitative Biosciences Institute (QBI) at the University of California, San Francisco (UCSF), to deliver multiple CRISPR-based engineered cell lines to accelerate the study of potential treatment targets for SARS-CoV-2, the novel coronavirus that causes COVID-19 disease.

A better understanding of the gut-brain axis may lead to new treatments for neurological disorders

Fri, 10/16/2020 - 12:05
Anyone who has experienced "butterflies in the stomach" before giving a big presentation will be unsurprised to learn there is a physical connection between their gut and their brain.

Patients with soft-tissue cancer show rapid and complete response to novel combination of immunotherapy

Fri, 10/16/2020 - 12:03
A patient with end-stage and rapidly progressing soft-tissue cancer whose tumor did not respond to standard treatment, had a "rapid and complete response" to a novel combination of immunotherapy, according to new research published by a team of scientists from John Theurer Cancer Center at Hackensack University Medical Center and the Georgetown Lombardi Comprehensive Cancer Center, both of whom are part of the Georgetown Lombardi Comprehensive Cancer Center Consortium.

Impact of COVID-19 on Australians with hypertension

Fri, 10/16/2020 - 11:56
Ten months into the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is unclear how people with hypertension are coping, given their increased risk. A retrospective case-control study compared people with hypertension to matched healthy controls during COVID-19 lockdown to determine whether they have higher risk perceptions, anxiety, and prevention intentions. The study is published on the preprint server medRxiv* in October 2020.

Scientists discover a novel antiviral strategy for treating COVID-19

Fri, 10/16/2020 - 11:54
A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU), has discovered a novel antiviral strategy for treatment of COVID-19.

Study: Combining sound and electrical stimulation of tongue can reduce tinnitus

Fri, 10/16/2020 - 11:53
In the largest clinical trial of its kind, researchers show that combining sound and electrical stimulation of the tongue can significantly reduce tinnitus, commonly described as "ringing in the ears." They also found that therapeutic effects can be sustained for up to 12 months post-treatment.

REFLECT II clinical trial evaluates safety and efficacy of cerebral embolic deflection filter

Fri, 10/16/2020 - 11:49
The REFLECT II randomized clinical trial evaluating the safety and efficacy of a device designed to reduce cerebral embolization and ischemic stroke, complications of transcatheter aortic valve replacement (TAVR), found that the device met the primary safety endpoint compared to historical controls but did not demonstrate superiority of the device for the primary hierarchical efficacy endpoint.

Rapid development of functionally diverse SARS-COV-2 mouse monoclonal antibodies

Fri, 10/16/2020 - 11:28
Now, a recent study published on the preprint server bioRxiv in October 2020 reports the development of a rapid process for generating high-affinity mouse mAbs, and their functional attributes.

Researchers examine the 'social brain' responsible for interacting with other people

Fri, 10/16/2020 - 11:20
A team of Russian researchers with the participation of a leading researcher at HSE University, Ekaterina Pechenkova, found that during group problem solving the components of the social brain are co-activated, but they do not increase their coupling during cooperation as would be suggested for a holistic network.

High-titer convalescent plasma reduced COVID-19 symptom severity in green monkeys

Fri, 10/16/2020 - 11:10
As scientists scramble to find effective vaccines and antivirals for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recent study published on the preprint server bioRxiv in October 2020 reports that the use of convalescent plasma to treat COVID-19 disease early in the course of the illness may be among the best available strategies at present.

Synthetic signals could help control tissue regeneration, guide cellular therapies

Fri, 10/16/2020 - 11:02
For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways.

Study: E-cigarettes may not be a safer alternative to smoking during pregnancy

Fri, 10/16/2020 - 10:59
E-cigarettes might not be a safer alternative to smoking during pregnancy, according to the first known study into the effects of prenatal nicotine exposure on babies.

A strategic collaboration to speed up the development of allogeneic cell therapies

Fri, 10/16/2020 - 10:56
The University of Texas MD Anderson Cancer Center and Allogene Therapeutics, Inc. today announced a strategic five-year collaboration agreement for the preclinical and clinical investigation of AlloCAR T candidates across Allogene's broad portfolio of hematologic and solid tumors.

Scientists reveal host pathways hijacked by three lethal coronaviruses

Fri, 10/16/2020 - 10:53
Seeking to inform development of drugs effective against multiple pathogenic human coronaviruses, David E. Gordon and colleagues compared host interactions of MERS-CoV, SARS-CoV-1 and SARS-CoV-2, uncovering host pathways commonly hijacked by all three.

Sexually active students more likely to use STI self-testing services

Fri, 10/16/2020 - 10:49
Sexually transmitted infections (STIs) are at record levels in the United States, with the Centers for Disease Control and Prevention reporting recent "steep and sustained" increases.