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Latest Medical Research News and Research
Updated: 13 min 21 sec ago

Researchers receive $500,000 grant to test novel approach for restoring damaged muscles after injury

Tue, 04/13/2021 - 01:48
Researchers from the University of Tennessee Health Science Center have received a $500,000 grant over three years from the Department of Defense to test a novel strategy using mitochondria transplantation therapy for restoration of neuromuscular structure and function after injury.

New test offers a simpler way to quantify the reservoir of intact viruses in HIV patients

Tue, 04/13/2021 - 01:41
A new test that measures the quantity and quality of inactive HIV viruses in the genes of people living with HIV may eventually give researchers a better idea of what drugs work best at curing the disease.

Novel immunotherapy approach may offer therapeutic advantages for melanoma

Tue, 04/13/2021 - 01:36
In a new study led by Yale Cancer Center, researchers have advanced a tumor-targeting and cell penetrating antibody that can deliver payloads to stimulate an immune response to help treat melanoma.

Early cannabis use may increase risk of developing heart disease

Tue, 04/13/2021 - 01:20
Smoking cannabis when you're young may increase your risk of developing heart disease later, according to a recent University of Guelph study.

Study demonstrates profound anhedonia in people with frontotemporal dementia

Tue, 04/13/2021 - 01:10
People with early-onset dementia are often mistaken for having depression and now Australian research has discovered the cause: a profound loss of ability to experience pleasure - for example a delicious meal or beautiful sunset - related to degeneration of 'hedonic hotspots' in the brain where pleasure mechanisms are concentrated.

Breast cancer survivors with excess body weight at increased risk of developing second cancer

Tue, 04/13/2021 - 00:57
Breast cancer survivors who are overweight have a statistically significant increased risk of developing second primary cancers, according to results from a study conducted by Kaiser Permanente researchers and published in the Journal of the National Cancer Institute.

Researchers reveal the positive effects of exercise on the liver

Tue, 04/13/2021 - 00:50
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide, affecting as much as a quarter of humanity. It is characterized by fat accumulation in liver cells and may progress to inflammation, cirrhosis and liver failure.

Broadly cross-reactive antibody to SARS-CoV-2 RBD with robust resistance to mutational escape

Mon, 04/12/2021 - 21:50
A new study addresses an urgent need – namely, a therapeutic antibody directed specifically against a key SARS-CoV-2 antigen which is highly conserved among similar viruses, and is not easily bypassed by viral escape mutations.

Small molecule inhibitors of SARS-CoV-2 identified by screening

Mon, 04/12/2021 - 21:33
A new study describes the identification of small molecule inhibitors that block the catalytic activity of the crucial viral non-structural protein 5 (nsp5), using a large-scale screening method.

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

Mon, 04/12/2021 - 21:19
A new preprint, recently released on the bioRxiv* server, explores the impact of a single mutation, the P681H mutation, on the transmissibility of the virus.

Current hygiene guidelines appropriate for UK and SA variants of SARS-CoV-2, study finds

Mon, 04/12/2021 - 21:04
Many different variants and lineages have arisen from the ancestral Wuhan-Hu1 strain of the SARS-CoV-2. This requires careful attention to control measures since many are more infective and transmissible than the older strains. A recent study compares the UK variant of this virus with the wildtype in terms of susceptibility to routine cleaning and disinfection measures.

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

Mon, 04/12/2021 - 19:09
A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the bioRxiv* preprint server.

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Mon, 04/12/2021 - 18:44
Even as vaccines against SARS-CoV-2 are being developed and administered at an unprecedented pace, treating this infection remains a challenge. To address this, researchers from China have used nanobodies (Nb) as a possible therapeutic approach. They reported Nb phage display libraries derived from four camels immunized with the SARS-CoV-2 spike RBD.

Imbalanced bacterial community in the gums linked to Alzheimer's disease biomarker

Mon, 04/12/2021 - 17:51
Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta--a key biomarker for Alzheimer's disease--in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill Cornell Medicine.

A shared set of systems in the brain may be vital for controlling the retrieval of facts and memories

Mon, 04/12/2021 - 17:38
A shared set of systems in the brain may play an important role in controlling the retrieval of facts and personal memories utilized in everyday life, new research shows.

SARS-CoV-2 spike E484K mutation reduces antibody neutralization

Mon, 04/12/2021 - 17:20
Researchers at the Department of Microbiology, Icahn School of Medicine at Mount Sinai New York, USA, showed that the SARS-CoV-2 spike E484K mutation reduces antibody neutralization.

Researchers work to develop dual antigen COVID-19 vaccine candidate

Mon, 04/12/2021 - 16:36
A new study has been published on the medRxiv* preprint server, which focuses on the development of a dual-antigen COVID-19' T cell' vaccine. This vaccine is developed based on the expression of both S protein and nucleocapsid (N) protein of SARS-CoV-2, using a next-generation human adenovirus serotype 5 (Ad5) platform.

Could N protein-based COVID-19 vaccines hinder SARS-CoV-2's NK cell inhibition?

Mon, 04/12/2021 - 15:15
Upon SARS-CoV-2 infection, what are the changes occurring on the surface of the host cell? To address this, and a team of researchers undertook a study exploring the natural killer (NK) cells and their role during a SARS-CoV-2 infection.

Tapeworm infection drug blocks SARS-CoV-2 damage in the lungs

Mon, 04/12/2021 - 11:53
New research published in the journal Nature found the presence of SARS-CoV-2 in the lungs resulted in abnormal pneumocytes and spike protein-mediated cell fusion. Their findings also showed that TMEM16F protein activation induces cell fusion. Therefore, drugs inhibiting the TMEM16F/Anoctamin6 calcium-activated ion channel, such as niclosamide, could serve as potential treatments for reducing the severity of COVID-19 infection.

COVID19's cytokine storm ushers in a local complement storm in the lungs

Mon, 04/12/2021 - 11:35
A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection.

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