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Updated: 54 min 20 sec ago

N501Y mutation in SARS-CoV-2 Delta variant is key to breakthrough infections

Tue, 10/26/2021 - 07:46
A study in the Philadelphia area found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants evolve to become more contagious and resistant to COVID-19 vaccines. In addition, depending on the sublineage, SARS-CoV-2 variants such as the Delta variant led to a three-fold increased risk for vaccine breakthrough cases.

CODA trial: Antibiotics now accepted as first-line treatment for people with appendicitis

Tue, 10/26/2021 - 07:34
Antibiotics are now an accepted first-line treatment for most people with appendicitis, according to final results of the Comparing Outcomes of antibiotic Drugs and Appendectomy (CODA) trial, and an updated treatment guideline for appendicitis from the American College of Surgeons.

SARS-CoV-2 delta variant generates infections more quickly than previous strains

Tue, 10/26/2021 - 07:24
Researchers in the UK have conducted a study suggesting that the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – is transmitted more quickly than previously circulating variants.

Air pollution reduces sperm count by causing brain inflammation, mice study shows

Tue, 10/26/2021 - 07:16
Researchers have long known that air pollution can increase the risk of disorders such as obesity, diabetes, and fertility, but they did not know the exact mechanism for how it can lead to these health conditions.

Stimulant use linked with increased risk of cardiovascular events among older adults in the first month

Tue, 10/26/2021 - 07:01
New research led by Mina Tadrous, Assistant Professor, Leslie Dan Faculty of Pharmacy, University of Toronto shows that use of prescription stimulant medications in older adults increased the risk of a cardiovascular events by 40 per cent within the first thirty days of medication use.

Fewer, higher doses of post-prostatectomy radiation therapy does not increase long-term side effects

Tue, 10/26/2021 - 06:12
Using fewer-;but higher-;doses of radiation to treat men with prostate cancer who had their prostates removed does not increase long-term side effects or lower their quality of life compared to conventional radiation treatment, a new, multi-institutional clinical trial shows.

COVID-19's impact on excess mortality in 2020 varied widely across Europe

Tue, 10/26/2021 - 06:09
A team of researchers has demonstrated that the impact of the coronavirus disease 2019 (COVID-19) pandemic on excess mortality varied widely both between and within five European countries in 2020.

Study finds link between genes and amount of bacterial toxins in the blood

Tue, 10/26/2021 - 05:57
Lipopolysaccharide, a virulence factor produced by bacteria, is a toxin that can cause a systemic inflammation via the circulation. In a recently completed study, genetic markers were discovered which are associated with a heightened lipopolysaccharide level in the blood.

Regulating blood insulin levels in obese, diabetic patients may help reduce COVID-19 risk

Tue, 10/26/2021 - 05:50
Keeping blood insulin levels within strict, healthy parameters is a daily goal for people with diabetes. But now, researchers from Japan have found that regulating blood insulin levels may even help lower the risk of getting COVID-19.

Study looks at effectiveness and ethics of financial incentives for low-risk clinical trials

Tue, 10/26/2021 - 05:30
Use of financial incentives in two low-risk randomized clinical trials did not present ethical issues, and in one of the trials, the incentives increased study participation, according to findings published in JAMA Internal Medicine.

Can targeting autophagy become a new approach to COVID-19 treatment?

Tue, 10/26/2021 - 05:26
In a recent review, the author discusses autophagy as a contributing mechanism of selected drugs that are currently being evaluated to treat COVID‐19.

Researchers investigate SARS-CoV-2 specific immunity in young Swedish adults

Tue, 10/26/2021 - 05:23
Researchers at Karolinska Institutet in Sweden have analyzed the presence of SARS-CoV-2-specific antibodies and memory cells of the immune system in young adults.

UC study finds coping mechanisms that helped COVID-19 patients deal with loss of smell

Tue, 10/26/2021 - 05:19
One of the most common and disturbing side effects of COVID-19 is the loss of the sense of smell. New research from the University of Cincinnati found some common coping mechanisms that helped COVID-19 patients deal with a lessened sense of smell, which severely impacts the sense of taste.

Genetic biomarker test predicts how men with high-risk prostate cancer will respond to treatment

Tue, 10/26/2021 - 05:14
A new meta-analysis finds that a genetic biomarker test accurately predicts how men with high-risk prostate cancer will respond to treatment with radiation and hormone therapy.

Case Western Reserve secures $16 million to understand the relation between substance use and HIV

Tue, 10/26/2021 - 04:54
The use of opioids, methamphetamines, cocaine and other stimulants is the second-most-common cause of exposure to HIV among those in the United States diagnosed with the virus that causes AIDS.

U of M Udall Center receives $11.3 million grant to continue research on deep brain stimulation for Parkinson’s disease

Tue, 10/26/2021 - 04:45
The Udall Center at the University of Minnesota Medical School was awarded a new $11.3 million grant from the National Institute for Neurological Disorders and Stroke to continue its work in deep brain stimulation (DBS) for Parkinson's disease.

A new vaccine approach that could prevent future pandemics

Mon, 10/25/2021 - 19:36
News-Medical speaks to Professor Tomohiro Kurosaki about how he has developed a new vaccine approach that could prevent future pandemics.

Development of light-based tool for the inactivation of SARS-CoV-2

Mon, 10/25/2021 - 18:23
Researchers from EMIT bio have developed a biological light unit that can sterilize surfaces, killing SARS-CoV-2.

Are non-human primates at risk of SARS-CoV-2 exposure through wastewater contact?

Mon, 10/25/2021 - 17:43
Researchers have been investigating the potential for SARS-CoV-2 to spread to NHP through wastewater.

Molecular features of SARS-CoV-2 variant receptor binding

Mon, 10/25/2021 - 17:07
Researchers have been investigating the changes in receptor binding in these variants that increase the danger they pose.