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Latest Medical Research News and Research
Updated: 42 min 32 sec ago

Children who snore regularly may have significant brain changes

Tue, 04/13/2021 - 17:44
Children who regularly snore have structural changes in their brain that may account for the behavioral problems associated with the condition including lack of focus, hyperactivity, and learning difficulties at school.

Researchers develop broad-spectrum SARS-CoV-2 RBD-based vaccine

Tue, 04/13/2021 - 15:34
In a recent bioRxiv* preprint, the large team of researchers evaluated a SARS-CoV-2 Spike receptor-binding domain ferritin nanoparticle protein vaccine (RFN) in a nonhuman primate challenge model. This study addresses the need for a next-generation, efficacious vaccine with an increased pan-SARS breadth of coverage.

Researchers identify SARS-CoV-2 antiviral compounds using protein assay

Tue, 04/13/2021 - 14:59
During the process of SARS-CoV-2 infection, once the virus penetrates the host cell, two open reading frames, ORF1a and ORF1ab, are translated. ORF1ab is responsible for the production of 16 nonstructural proteins (nsp). Several viral proteases such as 3CLpro and PLpro (papain-like protease) produce 1-16 nsps. A new study has been published in bioRxiv* preprint server, which deals with identifying drugs that are effective as PLpro inhibitors.

Measurable antibody response to mRNA COVID-19 vaccine in elderly care home residents

Tue, 04/13/2021 - 12:03
A new preprint research paper posted to the medRxiv* server explores the antibody response to COVID-19 vaccines in elderly residents of nursing homes in the USA. As of March 2021, there have been over 1.4 million infections from SARS-CoV-2 and over 175,000 deaths related to the pandemic among nursing home residents in the country.

ACE2 homology in laboratory and wild animals

Tue, 04/13/2021 - 11:40
A new preprint research paper posted to the bioRxiv server describes the conservation of an important receptor gene for the virus among several animal species that live in close contact or proximity to humans.

Zipper motif mediates SARS-CoV-2 spike trimerization within host cell membrane

Tue, 04/13/2021 - 11:24
A new preprint research paper posted to the bioRxiv* server describes the results of a nuclear magnetic resonance (NMR) study to determine the structure of the S protein transmembrane domain (TMD) and its membrane-proximal regions.

SARS-CoV-2 viable 21 days in blood, mucus, semen, urine, but just 24 hours in breast milk

Tue, 04/13/2021 - 10:56
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19), spreads through respiratory droplets and aerosols expelled when infected individuals cough, sneeze, breathe or sing.

Psychedelic drugs may work in multiple ways in the brain

Tue, 04/13/2021 - 10:50
University of Maryland School of Medicine (UMSOM) researchers have shown that psilocybin—the active chemical in “magic mushrooms”— still works its antidepressant-like actions, at least in mice, even when the psychedelic experience is blocked.

PCR-based reverse genetic system helps analyze SARS-CoV-2 mutations

Tue, 04/13/2021 - 10:44
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. We know that mutations in the genome of SARS-CoV-2 have occurred and spread, but what effect do those mutations have?

People who experience big dips in blood sugar levels consume more calories

Tue, 04/13/2021 - 10:41
New research shows that people who experience big dips in blood sugar levels, several hours after eating, end up feeling hungrier and consuming hundreds more calories during the day than others.

Monitoring CO2 to assess risk of indoor airborne SARS-CoV-2 transmission

Tue, 04/13/2021 - 10:33
In the study, which appeared on the pre-print server medRxiv, the team developed a general mathematical theory to predict airborne transmission risk from carbon dioxide (CO2) time series in real-time and clarify different estimates that steer the guideline. The study findings were based on the assessment of transmission risk and implementing the guideline by CO2 monitoring in university classrooms and office spaces.

Adequate levels of antioxidants may reduce HPV infection linked to cervical cancer development

Tue, 04/13/2021 - 10:33
A study led by Hui-Yi Lin, Ph.D., Professor of Biostatistics, and a team of researchers at LSU Health New Orleans Schools of Public Health and Medicine has found that adequate levels of five antioxidants may reduce infection with the strains of the human papillomavirus (HPV) associated with cervical cancer development.

New algorithm can predict which genes cause cancer

Tue, 04/13/2021 - 10:25
A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers in Berlin combined a wide variety of data, analyzed it with "Artificial Intelligence" and identified numerous cancer genes.

Experts review new studies on cardiovascular effects of cigarette smoking versus electronic cigarettes

Tue, 04/13/2021 - 10:22
Electronic cigarette (EC) use, or vaping, has both gained incredible popularity and generated tremendous controversy, but although they may be less harmful than tobacco cigarettes (TCs), they have major potential risks that may be underestimated by health authorities, the public, and medical professionals.

CityMD experience during the coronavirus pandemic in New York City

Tue, 04/13/2021 - 10:11
Limiting SARS-CoV-2 transmission requires an infected person to quarantine themselves for at least two weeks. New research published on the medRxiv* server highlights the vital role urgent care centers play during the COVID-19 pandemic in New York.

Overuse can contribute to high rate of arm injuries among youth players

Tue, 04/13/2021 - 10:09
With spring baseball season underway, Eric Makhni, M.D., a Henry Ford Health System sports medicine orthopedic surgeon, warns about how overuse can contribute to the high rate of arm injuries among youth players.

Researchers identify new potential mechanism for age-related macular degeneration

Tue, 04/13/2021 - 10:02
Using laboratory-grown roundworms as well as human and mouse eye tissue, University of Maryland School of Medicine (UMSOM) researchers have identified a new potential mechanism for age-related macular degeneration-;the leading cause of blindness among older adults.

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Tue, 04/13/2021 - 09:57
Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion.

New technology shows encouraging results for treating osteosarcoma

Tue, 04/13/2021 - 09:52
A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues.

Could Zebrafish larvae be a novel animal model for SARS-CoV-2?

Tue, 04/13/2021 - 09:44
Researchers based in Paris, France, have explored the potential use of zebrafish larvae as animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These larvae are small and cheap, so could prove a suitable medium for rapid mass testing of the disease.

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