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Updated: 45 min 25 sec ago

'Mini-brains' can be infected by SARS-CoV-2 virus

Wed, 07/01/2020 - 04:59
A multidisciplinary team from two Johns Hopkins University institutions, including neurotoxicologists and virologists from the Bloomberg School of Public Health and infectious disease specialists from the school of medicine, has found that organoids (tiny tissue cultures made from human cells that simulate whole organs) known as "mini-brains" can be infected by the SARS-CoV-2 virus that causes COVID-19.

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

Wed, 07/01/2020 - 04:50
The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that IQGAP1 is a signaling scaffold implicated in TNBC, but its mechanism is unknown.

Potential new biomarker could improve COVID-19 diagnosis

Wed, 07/01/2020 - 04:48
Researchers at Montpellier University Hospital have discovered that an interferon-inducible receptor expressed on monocytes could be a useful biomarker for the rapid triaging of patients suspected to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

In-home portable air cleaners reduce particulate exposure for cardiac patients

Wed, 07/01/2020 - 04:33
Using an in-home portable air cleaner (PAC) can significantly reduce exposure to fine-particle air pollutants - a major risk factor for cardiovascular events in people with pre-existing heart disease, reports a pilot study in the July issue of Journal of Cardiopulmonary Rehabilitation and Prevention.

New study will help primary care nurses better care for dementia patients

Wed, 07/01/2020 - 04:27
McLean Hospital's Brent P. Forester, MD, MSc, is heading a new study of a training model to help primary care nurses better care for patients with dementia.

Alternative antibiotics for unverified penicillin allergies likely unnecessary

Wed, 07/01/2020 - 03:56
Hospitalized patients who report an allergy to penicillin are often prescribed alternative antibiotics for infection that can be harmful, even though diagnostic testing or evaluations would show that the vast majority of these reported allergies could be disproven, according to researchers from Massachusetts General Hospital.

Novel brain pathology could improve diagnosis, treatment of neurodegenerative diseases

Wed, 07/01/2020 - 03:49
Bristol scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntington's disease.

A semi-empirical model to reproduce the brain states from wakefulness to deep sleep

Wed, 07/01/2020 - 03:43
The human brain is a complex system comprising 1010 non-linear units (neurons) that interact in 1015 sites (synapses).

Scientists discover mechanism involving key protein that predicts cancer progression and relapse

Wed, 07/01/2020 - 03:30
Cancer cases have been rising over the years and according to the statistics, the number of people living with cancer will continue to increase.

Survey: 47% of people use technology to communicate with their healthcare providers

Wed, 07/01/2020 - 03:18
New research shows that 47 percent of people are using technology to communicate with their healthcare providers, and less than a quarter are having conversations with their providers about using health information technology (HIT).

Ghana's efforts to eliminate malaria at risk as economy improves

Wed, 07/01/2020 - 03:04
Ghana's efforts to eliminate malaria could be in jeopardy as its improved economy results in reduced external funding for fighting malaria, a study suggests.

Researchers uncover a potentially promising strategy to target brain tumors

Wed, 07/01/2020 - 03:01
Gliomas with mutations in what are called the isocitrate dehydrogenase (IDH) genes are the most common brain tumors diagnosed in younger adults aged 18 to 45 years.

SARS-CoV-2 can infect heart cells in a lab dish, study shows

Wed, 07/01/2020 - 02:52
A new study shows that SARS-CoV-2, the virus that causes COVID-19 (coronavirus), can infect heart cells in a lab dish, indicating it may be possible for heart cells in COVID-19 patients to be directly infected by the virus.

A biocompatible polymer can help heal broken bones

Wed, 07/01/2020 - 02:47
Healing broken bones could get easier with a device that provides both a scaffold for the bone to grow on and electrical stimulation to urge it forward, UConn engineers reported on June 27 in the Journal of Nano Energy.

COVID-19 patients' blood can help identify people at greatest risk of severe illness

Wed, 07/01/2020 - 02:05
Doctors can examine COVID-19 patients' blood to identify those at greatest risk of severe illness and to pinpoint those most likely to need a ventilator, new research from the University of Virginia School of Medicine suggests.

COVID-19 triggers changes in blood platelets

Wed, 07/01/2020 - 01:42
Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious complications in some patients who have the disease, according to University of Utah Health scientists.

Novel vaccine that removes aged immune cells mitigates metabolic disorders in obese mice

Wed, 07/01/2020 - 01:23
Aging is a multifaceted process that affects our bodies in many ways. In a new study, researchers from Osaka University developed a novel vaccine that removes aged immune cells and then demonstrated an improvement of diabetes-associated metabolic derangements by vaccinating obese mice.

Stool microbial and metabolite signatures predict cirrhosis

Wed, 07/01/2020 - 01:00
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide, affecting an estimated one-quarter of the global population. It is a progressive condition that, in worst cases, can lead to cirrhosis, liver cancer, liver failure and death.

Glowing dye may illuminate tumors during surgery

Wed, 07/01/2020 - 00:51
"Clean margins" are a goal of cancer excision surgery. If even a small piece of cancerous tissue is left behind, it increases the likelihood of a local recurrence and spread of the disease, possibly reducing overall survival time.

Low to moderate alcohol drinking may preserve brain function in older age

Wed, 07/01/2020 - 00:23
Light to moderate drinking may preserve brain function in older age, according to a new study from the University of Georgia.